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Preparation of high-purity ellagic acid

A high-purity technology of ellagic acid, applied in the field of preparation of active ingredients in plants, can solve the problems of many steps, long cycle, poor appearance and color, etc., and achieve the effect of simple process

Active Publication Date: 2009-05-20
GUILIN NATURAL INGREDIENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gallnut is an animal's worm. Although it belongs to traditional Chinese medicine, it is limited to external use. Therefore, ellagic acid prepared from gallnut as a raw material cannot be used as a food additive.
The obtained ellagic acid is of lower quality, with poorer appearance and color
In addition, the above-mentioned method has many steps, long cycle, high production cost, and is not easy to be put into large-scale production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Extraction: The raw material is boiled and extracted twice with 5 times the dry weight of the raw material in pure water, each time for 0.5 hours, the extracts are combined, filtered, and the filtrate is concentrated in a vacuum until it is alcohol-free to obtain an extract;

[0022] (2) Hydrolysis: add concentrated sulfuric acid to the extract, the amount added is equivalent to 0.5 times of the extract, fully mix, let stand, separate solid and liquid, and collect the precipitate;

[0023] (3) Purification: add a sufficient amount of diethylamine in the precipitation, after fully dissolving, adjust the pH of the solution to be 1, leave standstill, and crystals are precipitated;

[0024] (4) Collect crystals, filter, and dry to obtain light yellow powder with a purity of 98.5%.

Embodiment 2

[0026] (1) Extraction: the raw material is boiled and extracted twice with 12 times the dry weight of the raw material in pure water or 90% ethanol aqueous solution, each time for 2.5 hours, the extracts are combined, filtered, and the filtrate is vacuum concentrated to no alcohol to obtain an extract;

[0027] (2) Hydrolysis: add hydrogen peroxide with a concentration of 3% to the extract, the amount added is equivalent to 1 time of the extract, fully mix, let stand, separate solid and liquid, and collect the precipitate;

[0028] (3) Purification: add a sufficient amount of triethylamine in the precipitation, after fully dissolving, adjust the pH of the solution to be 5, let it stand, and crystals will separate out;

[0029] (4) Collect crystals, filter, and dry to obtain light yellow powder with a purity of 99%.

Embodiment 3

[0031] (1) Extraction: the raw material is extracted twice by boiling 50% aqueous methanol solution of 10 times the dry weight of the raw material, each time for 2 hours, the extracts are combined, filtered, and the filtrate is vacuum concentrated to no alcohol to obtain an extract;

[0032] (2) Hydrolysis: adding concentration to the extractum is 50% hydrogen peroxide, the amount added is equivalent to 0.8 times of the extractum, fully mixed, left standstill, solid-liquid separation, and collect precipitation;

[0033] (3) Purification: add a sufficient amount of triethylamine in the precipitation, after fully dissolving, adjust the pH of the solution to be 3, let it stand, and crystals will separate out;

[0034] (4) Collect crystals, filter, and dry to obtain light yellow powder with a purity of 99.1%.

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Abstract

The invention discloses a preparation method of high-purity ellagic acid; tara powder is taken as raw material, extracted by purified water or 50-percent to 90-percent ethanol or a methanol water solution, hydrolyzed by concentrated sulfuric acid or hydrogen peroxide, purified by using diethylamine or triethylamine and crystallized, thus obtaining the high-purity ellagic acid; the method has simple technique and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a method for preparing active ingredients in plants, in particular to a method for preparing ellagic acid by using tara as a raw material. Background technique [0002] Ellagic acid (Ellagic Acid) is a polyphenolic compound widely present in pomegranate, tara, strawberry, grape, apple, cranberry, blackberry and walnut. It is an extremely effective antioxidant found so far. Effective against the production and deepening of melanin, compared with other traditional whitening ingredients, its miraculous antioxidant power has unique dual effects: first, ellagic acid can neutralize copper in cells, block copper ions from recombining with tyrosine, Thus affecting the production process of melanocytes, directly blocking the possibility of melanocytes forming melanin, greatly reducing the chance of new spots; secondly, even if melanin has been formed, ellagic acid can neutralize the harmful free radicals produced during the formation of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/06
Inventor 孙步祥梁远盛汤凌志李送军赵军
Owner GUILIN NATURAL INGREDIENTS CORP
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