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Leaf extract of Herba siegesbeckiae, preparation method and uses thereof

A technology for the leaves and extracts of A. chinensis, which is applied in the field of natural medicinal chemistry, can solve problems such as birth defects, and achieve the effects of low cost and high yield.

Inactive Publication Date: 2009-05-27
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Leflunomide (Arava) is a drug for the treatment of rheumatoid arthritis produced by Aventis, the largest pharmaceutical company in France, which caused 54 cases of liver failure or liver damage and 8 deaths. In addition, the drug can also cause birth defects

Method used

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  • Leaf extract of Herba siegesbeckiae, preparation method and uses thereof
  • Leaf extract of Herba siegesbeckiae, preparation method and uses thereof
  • Leaf extract of Herba siegesbeckiae, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Take 1500 g of dried scutellaria leaves, pulverize them, add 10 times of 95% ethanol to reflux and extract twice, each time for 1.0 hour, filter, combine the filtrates, concentrate to a solution with a relative density of 1.15 at 50°C, and pass through After the treated macroporous adsorption resin column D101 is eluted with 25% ethanol, the eluent is discarded, followed by elution with 80% ethanol, the eluted fraction is collected, concentrated to recover ethanol, and the relative density at 50°C is further concentrated The extract is 1.20, and vacuum-dried to obtain the extract of the leaves of Siberia chinensis.

[0020] (2) the preparation prescription of the present invention is:

[0021] 150 grams of the extract of the leaves of Westerus chinensis, 75 grams of starch, 75 grams of microcrystalline cellulose, 10 ml of 2% PVP ethanol solution, 20 grams of CMS-Na, 5 grams of magnesium stearate as pharmaceutical excipients;

[0022] (3) Weigh each preparation comp...

Embodiment 2

[0024] (1) Take 1200 g of dry Sisia chinensis leaves, pulverize them, add 8 times of 70% ethanol to reflux and extract 3 times, each time for 0.5 hours, filter, combine the filtrates, concentrate to a solution with a relative density of 1.05 when concentrated to 50 ° C, and pass through After the treated macroporous adsorption resin column D201 is eluted with 25% ethanol, the eluent is discarded, followed by elution with 80% ethanol, the eluted fraction is collected, concentrated to recover ethanol, and the relative density at 50°C is further concentrated The extract of 1.10 was vacuum-dried to obtain the extract of the leaves of Siberia chinensis.

[0025] (2) the preparation prescription of the present invention is:

[0026] 150 grams of the extract of the leaves of the scorpion grass, the medicinal excipients are 75 grams of starch, 75 grams of microcrystalline cellulose, 100 grams of lactose, 12 ml of 2% PVP ethanol solution, and 10 grams of magnesium stearate;

[0027] (...

Embodiment 3

[0029] (1) Take 1800g of dry Sisia chinensis leaves, crush them, add 6 times of 50% ethanol to reflux and extract 4 times, each time for 1 hour, filter, combine the filtrates, concentrate to a solution with a relative density of 1.12 at 50°C, and pass After the treated macroporous adsorption resin column D301 is eluted with 25% ethanol, the eluent is discarded, followed by elution with 80% ethanol, the eluted fraction is collected, concentrated to recover ethanol, and the relative density at 50°C is further concentrated The extract is 1.15, and vacuum-dried to obtain the extract of the leaves of Siberia chinensis.

[0030] (2) 200 grams of the extract of the leaves of the sage, the medicinal excipients are 200 grams of HPMC (K4M), and 10 grams of magnesium stearate;

[0031] (3) Weighing each preparation component, passing the extract of the leaves of Sickles grass and the above auxiliary materials through an 80-mesh sieve, mixing evenly, and pressing into tablets to obtain 10...

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Abstract

The invention discloses a common St. Paulswort herb leaf extract which takes leaves of the common St. Paulswort herb as the raw material and is obtained by means of alcohol-extraction. The invention also discloses a method for preparing the common St. Paulswort herb leaf extract and further discloses a pharmaceutical composition taking the common St. Paulswort herb leaf extract as the active component; in addition, the invention also discloses the application of the common St. Paulswort herb leaf extract in the aspect of curing rheumatic arthritis, rheumatoid arthritis, gout, scapulohumeral periarthritis and other diseases.

Description

technical field [0001] The present invention relates to the field of natural medicinal chemistry, in particular, to the extract of the leaves of the traditional Chinese medicine Siberia chinensis, its preparation method, the pharmaceutical composition with the extract as the active ingredient and the use of the extract in the preparation and treatment of rheumatoid arthritis and rheumatoid arthritis. Application in pharmaceutical preparations for acute arthritis, gout, and frozen shoulder. Background technique [0002] Rheumatoid arthritis is one of the clinical manifestations of rheumatic fever. The typical manifestation is migratory polyarthritis, which often symmetrically involves large joints such as knees, ankles, shoulders, wrists, elbows, and hips; local inflammation is red, swollen, hot, and painful, but not suppurative. In some patients, several joints are affected at the same time, and the small joints of hands, feet, or spinal joints can also be involved. At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P29/00A61P19/02A61P19/06A61K127/00
Inventor 程志红
Owner SHANGHAI INST OF PHARMA IND CO LTD
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