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Loratadine orally disintegrating tablet and technique for preparing the same

A technology of orally disintegrating tablets and loratadine, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pill delivery, which can solve problems such as inconvenient carrying, inconvenient, and affecting drug compliance

Inactive Publication Date: 2009-06-24
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is estimated that about 50% of people have difficulty swallowing tablets and capsules which affects medication compliance
In addition, ordinary tablets and capsules of loratadine must be disintegrated in the stomach to start releasing the drug, and the onset of action is slow, and it is very inconvenient to take it with water
Although the liquid preparation is convenient to take orally and has a quick effect, it requires a certain amount and a container for carrying it, which is very inconvenient to carry

Method used

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  • Loratadine orally disintegrating tablet and technique for preparing the same
  • Loratadine orally disintegrating tablet and technique for preparing the same
  • Loratadine orally disintegrating tablet and technique for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

Embodiment 2

[0052]

[0053] Preparation Process

[0054] (1) loratadine is crushed and passed through a 100-mesh sieve;

[0055] (2) Xylitol, starch and croscarmellose sodium are respectively sieved with 80 meshes:

[0056] (3) orange essence, ethyl cellulose, sucrose, magnesium stearate pass through 60 mesh sieves, respectively, for subsequent use;

[0057] (4) Place the loratadine, ethyl cellulose, starch, and xylitol of the recipe quantity in a rapid stirring granulator, and mix them uniformly according to the principle of equal increments;

[0058] (5) turn on stirring, add water to granulate;

[0059] (6) Ventilation drying at 40℃-60℃, 30 mesh granulation;

[0060] (7) Mix the sucrose, orange essence, and croscarmellose sodium in the prescribed proportions with the granules with a high-efficiency mixer;

[0061] (8) take by weighing the magnesium stearate of recipe quantity, mix with above-mentioned granule with high-efficiency mixer;

[0062] (9) Measure the content of the mai...

Embodiment 3

[0069]

[0070]

[0071] Preparation Process

[0072] (1) loratadine is crushed and passed through a 100-mesh sieve;

[0073] (2) Sorbitol, starch, crospovidone pass through 80 mesh sieves respectively:

[0074] (3) Grape essence, ethyl cellulose, stevioside, and micropowder silica gel are respectively sieved with a 60-mesh sieve, for subsequent use;

[0075] (4) Place the loratadine, ethyl cellulose, starch, and sorbitol of the recipe quantity in a rapid stirring granulator, and mix them uniformly according to the principle of equal increments;

[0076] (5) turn on stirring, add water to granulate;

[0077] (6) Ventilation drying at 40℃-60℃, 30 mesh granulation;

[0078] (7) Mix the stevioside, grape essence and crospovidone of the prescription ratio with the granules with a high-efficiency mixer;

[0079] (8) take by weighing the micropowder silica gel of recipe quantity, mix with above-mentioned particle with high-efficiency mixer;

[0080] (9) Measure the conten...

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Abstract

The invention relates to a loratadine orally disintegrating tablet consisting of a special preparation and a preparation method thereof. The loratadine orally disintegrating tablet contains pharmaceutical excipients such as a disintegrant, a filling agent, an adhesive, a flavoring agent, a sweetening agent, a lubricating agent and so on, and can be used for the treatment of anaphylactic diseases.

Description

technical field [0001] The invention relates to a loratadine oral pharmaceutical composition with a specific composition ratio and a preparation method thereof, in particular to a loratadine oral disintegrating tablet and a preparation method thereof. Background technique [0002] Loratadine has been listed in most countries since it was listed in 1988. It is sold as an over-the-counter drug in 15 countries. In 1988, the sales amounted to 2.3 billion US dollars. It is expected to reach 10 billion US dollars in 2007. Large-scale production of chlorine Retadine has good social and economic benefits. [0003] As the average human lifespan increases and the ability to swallow decreases with age, oral tablet administration has become a concern. It is estimated that about 50% of people have difficulty swallowing tablets and capsules which affects drug compliance. In addition, ordinary tablets and capsules of loratadine must be disintegrated in the stomach to start releasing the ...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K9/20A61K47/38A61P37/08
Inventor 李文斌
Owner AVENTIS PHARMA HAINAN
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