Method for industrial production of bezoar by chemical method

A chemical method, bezoar technology, applied in the direction of medical formula, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems of high cost, complicated cultivation process, low yield, etc., to achieve industrial production, simple process, The effect of stable quality

Active Publication Date: 2009-06-24
山东尚端生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of bezoar substitutes is not ideal, and the curative effect is not good
At present, some scientific researchers have carried out the so-called in vitro cultivation of bezoar, which is actually a formula; after testing and testing, its curative effect is not

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0015] Embodiment one:

[0016] Take 3100-3200g of cow bile, add 2g of sodium borohydride and 5g of calcium chloride, stir evenly, then heat to 39-42°C, keep warm for 15-20 minutes, carry out reduction, hydrolysis and salt-forming reactions, and produce precipitates, then Discard the supernatant, take the precipitate, dry it and crush it, which is the prepared bezoar.

Example Embodiment

[0017] Embodiment two:

[0018] Take 3400-3500g of sheep bile, add 2-2.2g of sodium borohydride and 5.2-5.5g of calcium chloride, stir evenly, then heat to 40-42°C, keep warm for 15-20 minutes, and carry out reduction, hydrolysis and salt-forming reactions , produce a precipitate, then discard the supernatant, take the precipitate, dry it and pulverize it, which is the produced bezoar.

Example Embodiment

[0019] Embodiment three:

[0020] Take 3000-3100g of pig bile, add 1.8-2g of sodium borohydride and 4.5-4.8g of calcium chloride, stir evenly, then heat to 43-45°C, keep warm for 15-20 minutes, and carry out reduction, hydrolysis and salt-forming reactions. Produce sediment, then discard the supernatant, take the sediment, dry and pulverize, which is the produced bezoar.

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PUM

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Abstract

The invention relates to a method for completing chemical process of generating the bezoar in vitro by a chemical method to realize industrial production by taking bile of animals such as cattle (pigs, sheep and birds) as a raw material and simulating the biochemical process of bezoar in an ox-gall. The method comprises: firstly, adding sodium borohydride and calcium chloride into the bile of the animals such as the cattle (the pigs, the sheep and the birds), and uniformly stirring the mixture, wherein the weight ratio of the bile of the animals to the sodium borohydride to the calcium chloride is 3,000-3,500:1.8-2.2:4.5-5.5; heating the mixture to be between 39 and 45 DEG C, maintaining at the temperature for 15 to 20 minutes, performing reduction, hydrolysis and salt-forming reaction, and generating deposit; and thirdly, removing supernatant, taking the deposit, drying and crushing the deposit, and preparing the bezoar. The method for cultivating the bezoar through biosynthesis by the chemical method in vitro has simple technological process, and is easy to operate; the prepared bezoar has the same treatment effect with natural bezoar, and is even superior to the natural bezoar in certain aspects; and the method can realize industrial production, and has the characteristics of high yield, stable quality, small investment, low cost and so on.

Description

1. Technical field [0001] The invention relates to a method for simulating the biochemical process of bezoar in bovine gallbladder by using bile of animals such as cattle (pigs, sheep, poultry) as raw materials, completing the chemical process of forming bezoar in vitro, and realizing industrial production. 2. Background technology [0002] Calculus Calculus is a precious traditional Chinese medicine, which has the effects of clearing away heat, detoxification, calming convulsions, and eliminating phlegm. It has a significant curative effect on diseases such as salivation. But the output of natural bezoar is seldom, especially in my country, which only accounts for about 1% of the demand, which is far from satisfying the needs of my country, and a very large part of bezoar depends on imports. For this reason, in recent years, the substitute of bezoar has been researched. Yet the effect of bezoar substitute is unsatisfactory, and curative effect is not good. At present, so...

Claims

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Application Information

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IPC IPC(8): A61K35/413
Inventor 周广礼高允生赵晓民刘化侠周春国
Owner 山东尚端生物科技有限公司
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