Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for synthesizing natural sesquiterpene Crepis virens extract (8-Epigrosheimin)

A sesquiterpene lactone and synthetic method technology, applied in the field of chemical synthesis, can solve the problems of large side effects, carcinogenicity, poor effect, etc., and achieve the effect of simple operation and high yield

Inactive Publication Date: 2009-07-15
NANKAI UNIV
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for the treatment of amoebiasis. Many of these drugs have serious side effects, such as carcinogenesis, inhibition of eukaryotic protein synthesis, high toxicity, and neuromuscular blocking effect.
There is no further report on the synthesis and activity of this compound

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for synthesizing natural sesquiterpene Crepis virens extract (8-Epigrosheimin)
  • Method for synthesizing natural sesquiterpene Crepis virens extract (8-Epigrosheimin)
  • Method for synthesizing natural sesquiterpene Crepis virens extract (8-Epigrosheimin)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] The synthesis of key intermediate 2-methyl-3-methoxymethyl-5-isopropenyl-cyclopentanecarbaldehyde (5-Isopropenyl-3-methoxymethoxy-2-methyl-cyclopentanecarbaldehyde) of the present invention refers to literature method to synthesize, the yield is 50%. (Lee E, Yoon C H. Stereoselective favorskii rearrangement of carvone chlorohydrin: Expedient synthesis of (+)-dihydrone petalactone and (+)-iridomyrmecin. JChem S, Chem Commun, 1994: 479~481)

[0029] 1. Synthesis of intermediate 3-bromomethyl-5H-furan-2-one:

[0030]

[0031] Synthesis of Compound 1a

[0032]Add 42g of 1,4-butyrolactone and 5.7g of red phosphorus to a 500mL four-neck flask (thermometer, reflux condenser, dropping funnel, electromagnetic stirrer), stir for 0.5h, then add 28mL of liquid bromine under an ice bath, and dropwise Afterwards, the temperature rose to 70°C, and 28 mL of Br2 was added dropwise again. After the drop, the temperature rose to 80°C, reacted for 3 hours, cooled, blown in air, and to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a synthetic method of natural sesquiterpene lactone crepin (8-Epigrosheimin) with anti-ameba protozoon activity. The method comprises the following steps: synthesizing 2-methyl-3-methoxyl methyl-5-isopropenyl-cyclopentanealdehyde which is obtained by synthesizing carvone with 3-bromomethyl-5H-furan-2-one which is obtained by synthesizing by 1,4-butyrolactone under an action of zinc to obtain an intermediate A; performing alkali ring opening followed by acidification to obtain an intermediate B; performing Michael addition on thiophenol to obtain an intermediate C; oxidizing with Swern, and cyclizing with the catalysis of Lewis acid to obtain an intermediate D; regenerating double bonds by oxidization and thermal elimination to obtain an intermediate E; and performing deprotection and selective oxidation to obtain a target compound. The method is characterized by conveniently obtaining the optically pure target compound by using only one protective group without any other chiral reagents, catalyst or noble metal, and realizing first total synthesis of the compound. The material is easily obtained, the operation is simple, and the yield is high. The compound is expected to have great treatment application as a specific drug for treating amebic liver abscess.

Description

technical field [0001] The present invention relates to the chemical synthesis of active substances of sesquiterpene lactones in natural plants, in particular a method for the total synthesis of natural sesquiterpene lactones (8-Epigrosheimin) with anti-amoeba activity, Specifically, starting from readily available raw materials in the market, stereospecific and enantioselective synthesis is used to obtain optically pure natural products. The compound can be used as a bactericidal and anti-amoeba drug or its precursor. Background technique [0002] Amoeba can parasitize in human or animal tissue. The protozoan mostly parasitizes the intestines and livers of humans and animals, and rarely parasitizes the lungs, brain, and spleen, and invades the body in the form of trophozoites, thereby causing amoebic dysentery (expressed as acute and chronic amoebic dysentery) ) or extraintestinal infection (ie amebic liver abscess). Amebic enteropathy can cause many serious complication...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D307/93C07D307/58A61P33/02
CPCY02P20/55
Inventor 徐效华杨海申乔晓晓谢龙观
Owner NANKAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com