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Ginkgo ketone ester dispersible tablet and preparation method thereof

A technology of ginkgo ketone esters and dispersible tablets, which is applied in the field of medicine, can solve the problems of affecting the dissolution and absorption of lactones and flavonoids, and the low dispersion of fine powder, and achieve good disintegration and dissolution effects, excellent dispersion performance, and complete tablet shape Effect

Active Publication Date: 2011-12-14
BEIJING SIHUAN KEBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But because the ginkgo terpene lactones in the ginkgo ketone esters are insoluble in water, and the aglycones in the flavonoids are also insoluble in water, the dispersibility of the fine powder of the ginkgo ketone esters is low, which affects the dissolution and absorption of the lactones and flavonoids. It is generally believed that adding a large amount of disintegrants can make the dispersible tablet reach the effect of rapid disintegration, therefore, the disintegrating agent used in the patent of CN101084890A accounts for 18-30% of the total amount

Method used

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  • Ginkgo ketone ester dispersible tablet and preparation method thereof
  • Ginkgo ketone ester dispersible tablet and preparation method thereof
  • Ginkgo ketone ester dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] Ginkgo ketone ester 40g, mannitol 30g, pregelatinized starch 30g

[0136] Microcrystalline Cellulose 150g Croscarmellose Sodium 24g Aspartame 9g

[0137] Citrate 3g, Sodium Carboxymethyl Starch 24g, Magnesium Stearate 3g

[0138] Pressed into 1000 pieces

[0139] Weigh the prescription amounts of Ginkgo ketone ester, mannitol, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, aspartame, and citric acid and mix them uniformly by an equal amount incremental addition method. Add 95% ethanol to make soft material, granulate with a 20-mesh sieve, blow dry at 60°C, granulate with a 20-mesh sieve, add the recipe amounts of sodium carboxymethyl starch and magnesium stearate, mix well, and press into tablets with a pressure of 5kg .

Embodiment 2

[0141] Ginkgo ketone ester 40g Mannitol 50g Microcrystalline cellulose 150g

[0142] Croscarmellose Sodium 50g Aspartame 9g Citric Acid 3g

[0143] Magnesium Stearate 3g

[0144] Pressed into 1000 pieces

[0145] Weigh the prescription amounts of Ginkgo ketoester, mannitol, microcrystalline cellulose, croscarmellose sodium, aspartame, and citric acid and mix them evenly by an equal amount incremental addition method. Add 95% ethanol to make soft material, granulate with a 20-mesh sieve, blow dry at 60°C, granulate with a 20-mesh sieve, add the prescription amount of magnesium stearate, mix well, and press into tablets with a pressure of 5kg.

Embodiment 3

[0147] Ginkgo ketone ester 40g Mannitol 40g Pregelatinized starch 20g

[0148] Microcrystalline Cellulose 140g Croscarmellose Sodium 30g Aspartame 7g

[0149] Citrate 7g, Sodium Carboxymethyl Starch 15g, Magnesium Stearate 4g

[0150] Pressed into 1000 pieces

[0151] Weigh the prescription amounts of Ginkgo ketone ester, mannitol, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, aspartame, and citric acid and mix them uniformly by an equal amount incremental addition method. Add 80% ethanol to make soft material, granulate with a 20-mesh sieve, blow dry at 60°C, granulate with a 20-mesh sieve, add the recipe amounts of sodium carboxymethyl starch and magnesium stearate, mix well, and press into tablets with a pressure of 5kg .

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PUM

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Abstract

The invention discloses a ginkgo ketone ester dispersible tablet for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The invention screens the type, dosage and joint use of the disintegrating agent of the ginkgo ketone ketone dispersible tablet, as well as the composition and composition of other fillers. The ratio and the selection of the corresponding optimized process conditions make the prepared dispersible tablets disintegrate, dissolve quickly, and have high bioavailability; the administration methods are diverse and convenient, and the patient's compliance is good; the process is reasonable, the production scale is feasible, and the product quality is stable.

Description

technical field [0001] The invention relates to a ginkgo ketone ester dispersible tablet for treating cardiovascular and cerebrovascular diseases, and a preparation method of the dispersible tablet, belonging to the technical field of medicine. Background technique [0002] Ginkgo ketone ester has the functions of promoting blood circulation and removing stasis, and dredging and relaxing collaterals. , [0003] Dementia etc. [0004] On the market, ginkgo ketone ester preparations mainly include granules and dropping pills. CN101084890A discloses a ginkgo ketone ester dispersible tablet and a preparation method thereof. The dispersible tablet is composed of 15-35% of ginkgo ketone ester, 18-30% of disintegrant, 35-55% of filler, Flavor 0-3% is prepared. The preparation method adopts the method of adding the raw and auxiliary materials in an equal amount to mix uniformly, granules with 40-80% ethanol, drying and tableting. [0005] However, because the ginkgo terpenoid l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/16A61P9/10
Inventor 张建立曹相林
Owner BEIJING SIHUAN KEBAO PHARM CO LTD