Oral compositions, their preparation and use

A technology of composition and mixture, which is applied in the direction of drug combination, toiletry preparations, medical preparations of non-active ingredients, etc., and can solve problems such as unstable preparations

Active Publication Date: 2009-07-29
ORAIDENT LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Efforts to prepare formulations, particularly buccal formulations, including hyaluronic acid and other antibacterial agents such as chlorhexidine have failed due to the instability of the resulting formulations

Method used

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  • Oral compositions, their preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1: the preparation of stoste

[0096] (a) Preparation of HPLC45

[0097] The starting material consists of the mesocarp of immature bitter (blood / red) oranges, such as Seville citruses, which are classified as "unfit for consumption" and whose pits, pulp and oily peel have been Basically removed. The starting material is crushed and pressed in water / ethanol at a ratio of 1:10-20 (solvent:starting material). The resulting mixture is filtered to retain the water-soluble biomass and discard the insoluble biomass. Then the water-soluble biomass was further finely filtered to obtain a brown hygroscopic powder (HPLC45) after flash evaporation. Alternatively, HPLC45 is available from Exquim (Grupo Ferrer).

[0098] (b) Bioflavonoid composition by HPLC45

[0099] Analysis of the HPLC45 obtained in step (a) showed that 45% of the total composition of the HPLC45 was bioflavonoids, with the remainder (55%) comprising pectin, sugars and lower organic acids. Th...

Embodiment 2A

[0110] Example 2A: Spout Potion

[0111] ingredients

percentage

Glycerin

10.000

ethanol

15.000

xylitol

2.000

Polysorbate 20

1.500

Stock solution, pH adjusted to 6.44

1.000

flavoring agent

0.200

sodium saccharin

0.080

cetylpyridinium chloride

0.050

Disodium hydrogen phosphate·12H 2 o

0.075

Sodium hyaluronate

0.005

water

Top up to .100%

[0112] A. Laboratory sample: a spout potion based on the present invention, prepared by using the above-mentioned ingredients as follows: In the container (A), disperse sodium hyaluronate in water while stirring to obtain a solution without agglomeration. Add sodium saccharin, cetylpyridinium chloride, disodium phosphate, xylitol and stock solution and stir until all ingredients are completely dissolved. Add glycerin and mix well. In a separate container (B), the polysorbate 20, flavor and ethanol w...

Embodiment 2B

[0114] Example 2B: Spout Potion

[0115] ingredients

[0116] The spout liquid medicine of the present invention can be prepared in the above method with the above-mentioned ingredients.

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PUM

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Abstract

An oral composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1 % to <10% w / w (based on the total weight of the oral composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof; and (b) water; and, optionally, (c) a pharmaceutically acceptable carrier therefor.

Description

technical field [0001] The present invention relates to flavonoid-containing compositions for the preparation of compositions such as creams, gels, toothpastes, mouthwashes or dental rinses, comprising the sodium salt of high molecular weight hyaluronic acid. In particular, it relates to a composition, preferably an oral composition, comprising an antibacterial bioflavonoid stock solution combined with a sodium salt of high molecular weight hyaluronic acid, and its preparation and use. Background technique [0002] Certain compositions are known comprising flavonoids which have antimicrobial activity, in particular antibacterial activity, especially antiviral activity. However, the term "flavonoids" covers a large variety of different compounds that can be obtained from various natural sources. Depending on the source and nature or method of extraction, the overall chemical composition of the resulting flavonoid mixture may vary considerably. The biological activity of var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q11/00
CPCA61K8/602A61K8/676A61Q11/00A61K8/365A61K8/498A61K8/97A61K8/416A61K8/735A61K8/9789A61P1/02A61P17/00A61P17/02A61P31/04A61P43/00Y02A50/30A61K8/35A61K31/194A61K8/362A61K9/0014A61K9/0053A61K31/7048A61K31/728A61K36/752A61K47/12
Inventor 伊恩·里普莱霍华德·汤马斯
Owner ORAIDENT LTD
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