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Application of forsythiaside B in preparing medicament for treating or preventing acute and chronic liver damnification and liver fibrosis

A technology of liver fibrosis and forsythiaside, which is used in the field of medicines for treating liver diseases

Inactive Publication Date: 2012-09-05
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmacological effects of forsythiaside B in treating acute and chronic liver injury and liver fibrosis have not been reported. Based on this, the inventors have invented a method for the prevention and treatment of acute and chronic liver injury and liver fibrosis by forsythiaside B through a large number of experimental studies. Drug use in fibrosis

Method used

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  • Application of forsythiaside B in preparing medicament for treating or preventing acute and chronic liver damnification and liver fibrosis
  • Application of forsythiaside B in preparing medicament for treating or preventing acute and chronic liver damnification and liver fibrosis
  • Application of forsythiaside B in preparing medicament for treating or preventing acute and chronic liver damnification and liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0010] Preparation Example 1: Preparation of Forsythiaside B

[0011] Take 20kg of unique medicinal material, crush it, pass through a 10-mesh sieve, add 8 times the amount (V / W) of 80% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, recover the ethanol from the extract until it has no alcohol smell, filter , the filtrate was treated on the polyamide column, washed with water for 6 times the column volume and discarded, continued to elute with 10% ethanol for 4 column volumes, collected the eluate, put it on the treated polyamide column, washed with water until the effluent was colorless, and then 4 times the column volume was eluted with 5% ethanol, and the 5% ethanol eluate was collected and evaporated to dryness to obtain forsythiaside B with a content of 95%.

preparation example 2

[0012] Preparation Example 2: Preparation of Forsythiaside B

[0013] Take 20kg of unique medicinal material, crush it, pass through a 10-mesh sieve, add 20 times the amount (V / W) of 85% ethanol for percolation extraction, recover the ethanol from the extract until it has no alcohol smell, filter it, and put the filtrate on a polyamide column, Wash 6 times the column volume with water and discard, continue to elute with 10% ethanol for 4 column volumes, collect the eluate, put it on the treated AB-8 macroporous resin column, wash 2 times the column volume with water, discard, and then use 20% ethanol After 4 times of column volume was eluted, the eluate was collected and evaporated to dryness to obtain forsythiaside B with a content of 90%.

preparation example 3

[0014] Preparation Example 3: Forsythiaside B Solid Tablet

[0015] Preparation method: Measure forsythiaside B 25g, starch 25g, sodium carboxymethyl starch 50g, microcrystalline cellulose 50g, magnesium stearate 5g according to the prescription, mix, add 50% ethanol to granulate in an appropriate amount, dry, and granulate , compressed into tablets, and packed after passing the inspection.

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Abstract

The invention relates to application of forsythiaside B in preparing a medicine for treating or preventing hepatopathy, in particular to application of the forsythiaside B in preparing a medicine for treating or preventing acute and chronic hepatic injury and hepatic fibrosis. The medicine can be added with corresponding auxiliary materials according to the preparation requirements, adopts the form of injection, tablets, pills, granules, capsules, syrup and the like, and preferably adopts the form of freeze-dried powder and capsules. Various preparation formulations can be prepared by a conventional pharmaceutical method.

Description

technical field [0001] The invention relates to a medicine for treating liver diseases, in particular to the application of forsythiaside B in the preparation of medicines for preventing or treating acute and chronic liver damage and liver fibrosis caused by viruses, chemical substances and medicines. Background technique [0002] Forsythiaside B is extracted from Duyiwei. In vitro tests show that it has pharmacological effects such as neuroprotection, anti-atherosclerosis and anti-inflammation [Koo KA, Sung SH, Park JH, Kim SH, Lee KY, Kim YC. In vitamineuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma. Planta Med, 2005, 71(8): 778-80.; Martin-Nizard F, Sahpaz S, Kandoussi A, CarpentierM, Fruchart JC, Duriez P, Bailleul F. Natural phenylpropanoids inhibitlipoprotein-induced endothelin-l secretion by endothelial cells. J Pharm Pharmacol. 2004, 56(12): 1607-11.; Sahpaz S, Garbacki N, Tits M, Bailleul F. Isolation and pharmacological activity of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/16
Inventor 蒋王林徐本明彭湘林朱海波田京伟
Owner SHANDONG LUYE PHARMA CO LTD