Plant extract of the genus Zanthoxylum and its preparation method and use

A technology of Zanthoxylum genus and fruit peel extract, applied in the field of Zanthoxylum bungeanum plant extracts

Active Publication Date: 2011-12-21
CHENGDU DIAO JIU HONG PHARMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the chemical composition and pharmacological effects of the water-soluble part (accounting for 70% of the total extract) of Zanthoxylum, modern research is less

Method used

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  • Plant extract of the genus Zanthoxylum and its preparation method and use
  • Plant extract of the genus Zanthoxylum and its preparation method and use
  • Plant extract of the genus Zanthoxylum and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Zanthoxylum bungeanum plant extract

[0037] Take 1000g of green pepper (Z.schinifolium Sieb.et Zucc.) peel and use 10L of 70% acetone for reflux extraction for 3 times; the extract is concentrated in a vacuum to be acetone-free, and then applied to a HPD500 type macroporous adsorption resin column. Remove impurities such as sugar, and then eluted with 60% ethanol. The eluate is concentrated to a relative density of 1.10 and then precipitated with 5 times the amount of 95% ethanol. The precipitate is discarded. The supernatant is vacuum concentrated and spray dried to obtain a brown color. 62g of powdered Zanthoxylum spp. plant extract, tested to have a weight percentage of 80% of total polyphenols, of which the weight percentage of ZP-CT-A is 15%.

Embodiment 2

[0038] Example 2 Preparation of Zanthoxylum bungeanum plant extract

[0039] Take 1000g of bamboo leaf pepper (Z.armatum DC) peel, and use 20L of water for reflux extraction for 3 times; the extract is directly applied to the D101 macroporous adsorption resin column, first eluted with water to remove impurities such as sugar, and then washed with 20% acetone After the eluate was concentrated to a relative density of 1.20, it was precipitated with 4 times the amount of 95% ethanol. The precipitate was discarded. The supernatant was vacuum concentrated and spray-dried to obtain 92 g of Zanthoxylum spp. The weight percentage of the total polyphenols detected is 50%, and the weight percentage of ZP-CT-A is 5%.

Embodiment 3

[0040] Example 3 Preparation of Zanthoxylum bungeanum plant extract

[0041] Take 1000g of Z.bungeanum Maxim. peel and extract with 18L of 70% ethanol for percolation extraction; the extract is concentrated in a vacuum to be ethanol-free, and then applied to a HP20 type macroporous adsorption resin column, first eluted with water to remove impurities such as sugar Then it was eluted with 60% ethanol. The eluate was concentrated to a relative density of 1.15 and then precipitated with 3 times the amount of 95% ethanol. The precipitate was discarded. The supernatant was vacuum concentrated and spray dried to obtain a brown powdery Zanthoxylum spp. The plant extract is 43 g, and the weight percentage of the total polyphenols is 74%, and the weight percentage of ZP-CT-A is 12%.

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Abstract

The invention provides a plant extract of the genus Zanthoxylum and its preparation method and application. The plant extract of the genus Zanthoxylum is extracted and refined from the peel of the plant of the genus Zanthoxylum L., and its total polyphenol content is 50-80%. 15%. The Zanthoxylum plant extract is combined with a pharmaceutically acceptable carrier or other suitable excipients, and made into oral, injection or other dosage forms according to conventional methods, which can be used for the prevention and treatment of stroke, Parkinson's syndrome, Hypertension, hyperlipidemia, atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases.

Description

Technical field [0001] The invention relates to a Zanthoxylum bungeanum plant extract, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Zanthoxylum L. is a shrub or small tree of Rutaceae plants. There are about 250 species in the world, about 45 species and 13 varieties in my country. They are distributed in most areas of China. Its fruits, roots, stems, The leaves are used for medicinal purposes both at home and abroad, and have analgesic, anesthetic, antibacterial, insecticidal and anti-tumor effects. Materia Medica records the peel as "Jiaohong", which has the effects of warming the middle and dispelling cold, relieving pain and itching, killing insects and removing dampness; the seeds are called "Jiaomu" and have the effect of relieving asthma and diuresis. The main varieties of Zanthoxylum in my country are Zanthoxylum bungeanum Maxim., Green Pepper (Z.schinifolium Sieb.et Zucc.), ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61P3/06A61P7/02A61P9/10A61P9/12A61P25/26A61K131/00
Inventor 李麒麟晏菊芳李波张娟杨正平
Owner CHENGDU DIAO JIU HONG PHARMACEUTICAL FACTORY
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