Method of preparing taurine

Abstract

The invention relates to method for preparing taurine, comprising the following steps: (1) reacting epoxy ethane with sodium sulfite under 0.05 to 0.1MPa, with pH value of 6.5 to 7.5 and at temperature between 75 and 85 DEG C to obtain hydroxyethyl sodium sulfonate; (2) carrying out ammonolysis reaction on the hydroxyethyl sodium sulfonate and liquid ammonia under 14 to 21MPa and at temperature between 160 and 280 DEG C to obtain ammonolysis solution containing sodium taurate; (3) introducing the ammonolysis solution into a single flash evaporator for primary flash evaporating at a temperature between 160 and 200 DEG C and under 1.3 to 2.0MPa; introducing the flash evaporated liquid into a secondary flash evaporating and falling film evaporator, using the primary flash vapor as a heating medium to carry out flash evaporating and falling film evaporating on the primary flash evaporated liquid in the secondary flash evaporating and falling film evaporator at a temperature between 110 and 140 DEG C and at 0.1 to 0.6MPa; evaporating and concentrating the flash evaporated liquid subjected to secondary flash evaporating and falling film evaporating with flash vapor and steam as heating media in a multi-effect flash evaporating and falling film evaporator; and (4) neutralizing the sodium taurate by sulphuric acid to obtain the taurine. The method for preparing the taurine has the advantages of short time, high yield and low cost, and is easy for industrialized production. In addition, by primary flash evaporating and secondary flash evaporating processes, almost all the ammonia and 40% to 60% of water in the flash evaporated liquid can be removed, thus having double effects of removing ammonia and condensing.

Description

technical field

[0001] The invention relates to a preparation method of taurine. Background technique

[0002] Taurine (chemical name 2-aminoethanesulfonic acid), pure product is colorless or white oblique crystal, odorless, stable chemical properties, soluble in organic solvents such as ether, because it was first extracted from ox bile in 1843 Therefore, it is named "Taurine" (Latin, meaning "amino acid from cattle"). It differs from other basic amino acids such as glutamic acid, lysine, methionine, alanine, serine, valine and threonine in that taurine does not directly participate in the synthesis of proteins, but is a free Special amino acids outside the cell. It is now known that taurine can play a variety of roles in the body, including detoxification, enhancing the stability of cell membranes, regulating the production of (brain) excitatory neurotransmitters, and intercellular calcium content, etc. Taurine is the most abundant sulfur-containing free radical amino a...

Examples

Embodiment 1

[0017] Preparation of sodium isethionate: react 1:1.2 molar ratio of ethylene oxide and sodium sulfite at 0.1MPa, pH 6.5-7.5 and 80°C for 1.2 hours to prepare sodium isethionate.

[0018] The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 3:1) (the consumption of catalyst is 1% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 20%, mass percentage) reacted for 45 minutes at 15MPa and 160°C, and the ammonolysis solution obtained by the ammonolysis reaction was passed into a flash through a decompression device. Carry out the first flash evaporation in the evaporator, the first flash evaporation temperature is 160°C, and the pressure is 1.3Mpa; the primary flash liquid and the primary flash steam from the primary flash evaporator are passed into the secondary flash falling film evapor...

Embodiment 2

[0022] Preparation of sodium isethionate: react 1:1.1 molar ratio of ethylene oxide and sodium sulfite at 0.07MPa, pH 6.5-7.5 and 75°C for 1.5 hours to prepare sodium isethionate.

[0023] The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 5:1) (the consumption of catalyst is 5% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 25%, mass percentage) reacted for 25 minutes at 21MPa and 280°C, and the ammonolysis solution obtained by the ammonolysis reaction was passed into a flash through a decompression device. The first flash evaporation is carried out in the evaporator, the first flash evaporation temperature is 200 °C, and the pressure is 2.0MPa; the primary flash liquid and primary flash steam from the primary flash evaporator are passed into the secondary flash falling film eva...

Embodiment 3

[0027] Preparation of sodium isethionate: react 1:1 molar ratio of ethylene oxide and sodium sulfite at 0.08MPa, pH 6.5-7.5 and 85°C for 1.1 hours to prepare sodium isethionate.

[0028]The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 4:1) (the consumption of catalyst is 3% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 30%, mass percentage) ammonolysis reaction at 17MPa and 190°C for 30 minutes, and the ammonolysis solution obtained by the ammonolysis reaction is passed through a decompression device The first flash evaporation is carried out in the primary flash evaporator, the first flash evaporation temperature is 170°C, and the pressure is 1.5MPa; the primary flash liquid and primary flash steam from the primary flash evaporator are passed into the secondary flash falling ...

technical field

[0001] The invention relates to a preparation method of taurine. Background technique

[0002] Taurine (chemical name 2-aminoethanesulfonic acid), pure product is colorless or white oblique crystal, odorless, stable chemical properties, soluble in organic solvents such as ether, because it was first extracted from ox bile in 1843 Therefore, it is named "Taurine" (Latin, meaning "amino acid from cattle"). It differs from other basic amino acids such as glutamic acid, lysine, methionine, alanine, serine, valine and threonine in that taurine does not directly participate in the synthesis of proteins, but is a free Special amino acids outside the cell. It is now known that taurine can play a variety of roles in the body, including detoxification, enhancing the stability of cell membranes, regulating the production of (brain) excitatory neurotransmitters, and intercellular calcium content, etc. Taurine is the most abundant sulfur-containing free radical amino a...

Examples

Embodiment 1

[0017] Preparation of sodium isethionate: react 1:1.2 molar ratio of ethylene oxide and sodium sulfite at 0.1MPa, pH 6.5-7.5 and 80°C for 1.2 hours to prepare sodium isethionate.

[0018] The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 3:1) (the consumption of catalyst is 1% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 20%, mass percentage) reacted for 45 minutes at 15MPa and 160°C, and the ammonolysis solution obtained by the ammonolysis reaction was passed into a flash through a decompression device. Carry out the first flash evaporation in the evaporator, the first flash evaporation temperature is 160°C, and the pressure is 1.3Mpa; the primary flash liquid and the primary flash steam from the primary flash evaporator are passed into the secondary flash falling film evapor...

Embodiment 2

[0022] Preparation of sodium isethionate: react 1:1.1 molar ratio of ethylene oxide and sodium sulfite at 0.07MPa, pH 6.5-7.5 and 75°C for 1.5 hours to prepare sodium isethionate.

[0023] The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 5:1) (the consumption of catalyst is 5% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 25%, mass percentage) reacted for 25 minutes at 21MPa and 280°C, and the ammonolysis solution obtained by the ammonolysis reaction was passed into a flash through a decompression device. The first flash evaporation is carried out in the evaporator, the first flash evaporation temperature is 200 °C, and the pressure is 2.0MPa; the primary flash liquid and primary flash steam from the primary flash evaporator are passed into the secondary flash falling film eva...

Embodiment 3

[0027] Preparation of sodium isethionate: react 1:1 molar ratio of ethylene oxide and sodium sulfite at 0.08MPa, pH 6.5-7.5 and 85°C for 1.1 hours to prepare sodium isethionate.

[0028]The preparation of sodium taurate: in the presence of catalyst sodium carbonate and sodium bicarbonate (the mol ratio of sodium carbonate and sodium bicarbonate is 4:1) (the consumption of catalyst is 3% of the quality of sodium isethionate) , sodium isethionate and liquid ammonia (the concentration of ammonia in the reaction solution is 30%, mass percentage) ammonolysis reaction at 17MPa and 190°C for 30 minutes, and the ammonolysis solution obtained by the ammonolysis reaction is passed through a decompression device The first flash evaporation is carried out in the primary flash evaporator, the first flash evaporation temperature is 170°C, and the pressure is 1.5MPa; the primary flash liquid and primary flash steam from the primary flash evaporator are passed into the secondary flash falling ...

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