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Medicament compound for treating digestive disease and the method for preparing the same

A technology for digestive diseases and compositions, applied in the field of combined preparations of omeprazole and trociproxil, to achieve the effects of eliminating the main pathogenic factors, reducing gastroesophageal reflux, regulating and restoring functions

Inactive Publication Date: 2009-08-26
广西方略药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] So far, the combination preparation of omeprazole and troxipide has not been seen in the prior art to jointly treat gastric ulcer, duodenal ulcer, acute and chronic gastritis, gastroesophageal reflux disease, functional Gastrointestinal disorders such as dyspepsia, especially for control of single PPI or H 2 - Gastroesophageal reflux disease not effectively treated by receptor antagonists

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Prepare each enteric-coated tablet containing active ingredient omeprazole 20mg and trociproxide 100mg, and its formula is:

[0047] Omeprazole 20g

[0048] Traxipide 100g

[0049] Lactose 100g

[0050] Microcrystalline Cellulose 60g

[0051] Poloxamer 2g

[0052] PVP-K30 6g

[0053] Magnesium Stearate 10g

[0054] Talc powder 20g

[0055] EUDRAGIT 5g

[0056] Appropriate amount of diethyl phthalate

[0057] Specific preparation method:

[0058]Omeprazole 20g, troxipide 100g, lactose 100g, and microcrystalline cellulose 60g passed through a 100-mesh sieve were placed in a KJZ-10 type fast stirring granulator and mixed at high speed for 2min, and poloxamer 2g (poloxamer ) was dissolved in 15ml of 5% PVP-K30 absolute ethanol solution as a binder, added, mixed rapidly for 3 minutes, granulated rapidly for 2 minutes, taken out, dried in a vacuum oven at 50°C for 4 hours, granulated with a 16-mesh sieve , add an appropriate amount of magnesium stearate, and press i...

Embodiment 2

[0060] Prepare each enteric-coated tablet containing active ingredient omeprazole 10mg and trociproxil 50mg, and its formula is:

[0061] Omeprazole 10g

[0062] Traxipide 50g

[0063] Lactose 70g

[0064] Microcrystalline Cellulose 40g

[0065] Poloxamer 1g

[0066] PVP-K30 4g

[0067] Magnesium Stearate 6g

[0068] Talc powder 12g

[0069] EUDRAGIT 5g

[0070] Appropriate amount of diethyl phthalate

[0071] Specific preparation method:

[0072] Prepared by basically the same method as in Example 1, a total of 1,000 omeprazole-traxipit enteric-coated tablets were prepared, each containing 10 mg of omeprazole and 50 mg of troxipide.

Embodiment 3

[0074] Prepare each capsule containing active ingredient omeprazole 20mg and troxipide 100mg, its formula is:

[0075] Omeprazole 20g

[0076] Traxipide 100g

[0077] Lactose 100g

[0078] Microcrystalline Cellulose 80g

[0079] Poloxamer 2g

[0080] PVP-K30 6g

[0081] EUDRAGIT 5g

[0082] Appropriate amount of diethyl phthalate

[0083] Specific preparation method:

[0084] Preparation of omeprazole enteric-coated granules: take 20 g of omeprazole, 20 g of lactose, and 20 g of microcrystalline cellulose that have been passed through a 100-mesh sieve, and place them in a KJZ-10 type fast stirring granulator for 2 minutes at high speed, and mix poloxa 0.5g (poloxamer) was dissolved in 15ml of 5% PVP-K30 absolute ethanol solution as a binder, added, mixed rapidly for 3 minutes, granulated rapidly for 2 minutes, taken out, and dried in a vacuum oven at 50°C for 4 hours. 24-40 mesh sieve for granulation. Add talcum powder into 5% PVP-K30 absolute ethanol solution, stir e...

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PUM

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Abstract

The invention discloses a medicament compound for treating digestive disease, wherein the weight ratio of omeprazole to troxipide as active ingredient is 1:1-1:10. The compound preparation can treat gastric ulcer, duodenal ulcer, acute and chronic gastritis, gastroesophageal reflux, functional dyspepsia, and the like. The compound preparation consisting of omeprazole and troxipide good in treating effect compared with a single medicament.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating digestive diseases, in particular to a combined preparation of omeprazole and troxipide. Background technique [0002] Omeprazole, alias: Anweiprazole; Omeprazole; Omeprazole; Oxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridyl)-methyl-sulfoxide}-1H-benzimidazole. Molecular formula: C17H19N3O3S, omeprazole is a proton pump inhibitor (PPI), which can prevent gastric acid secretion caused by various reasons. After PPI enters the human body, the action time can reach more than 24 hours. Therefore, PPI has a strong acid suppression strength and a long time. It can effectively relieve acid reflux, heartburn and other symptoms of gastroesophageal reflux disease clinically. [0003] In the prior art, a large number of technologies about omeprazole preparation form, compound form and the like are disclosed. For example, Chinese patent application 95194038.4 discloses a new oral pharmaceutical preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4462A61K31/4439A61P1/04A61P1/14
Inventor 杨进明王德武莫国飞
Owner 广西方略药业集团有限公司
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