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Pharmaceutical composition of blonanserin and preparation method thereof

A technology for compositions and mixtures, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, and can solve the problems of inability to obtain preparation products and inability to meet industrialization requirements.

Inactive Publication Date: 2009-09-16
北京德众万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adopting the technical scheme disclosed in EP0385237 cannot obtain a stable preparation product suitable for clinical use, and cannot meet the needs of industrialization.

Method used

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  • Pharmaceutical composition of blonanserin and preparation method thereof
  • Pharmaceutical composition of blonanserin and preparation method thereof
  • Pharmaceutical composition of blonanserin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] Preparation Process

[0025] Blonanserin is crushed through a 100-mesh sieve, mannitol, lactose, calcium hydrogen phosphate, and microcrystalline cellulose are respectively passed through a 80-mesh sieve, and magnesium stearate is passed through a 60-mesh sieve. Mix in a fast stirring granulator according to the prescription amount, add water-based soft material, pass through a 18-mesh sieve, dry in an oven at 55°C, pass through a 24-mesh sieve for granulation, add the prescription amount of magnesium stearate, and mix evenly Tablets, each containing 5mg of blonanserin.

Embodiment 2

[0027]

[0028] Preparation Process

[0029] Blonanserin is crushed through a 100-mesh sieve, mannitol, lactose, calcium hydrogen phosphate, and microcrystalline cellulose are respectively passed through a 80-mesh sieve, mixed in a fast stirring granulator according to the prescribed amount, added with water-based soft materials, and passed through a 18-mesh sieve Sieve, after drying in an oven at 55°C, pass through a 24-mesh sieve for granulation to obtain granules with uniform and full color, add the prescribed amount of micro-powder silica gel, mix well, and put them into capsule shells. Each capsule contains 5mg of blonanserin.

Embodiment 3

[0031]

[0032] Preparation Process

[0033] Blonanserin was crushed through a 100-mesh sieve, mannitol, lactose, calcium hydrogen phosphate, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose were respectively passed through a 80-mesh sieve, mixed in a fast stirring granulator according to the prescribed amount, added water The soft material is passed through a 18-mesh sieve, dried in an oven at 55°C, passed through a 24-mesh sieve for granulation, added the prescribed amount of magnesium stearate, mixed evenly, and pressed into tablets. Each capsule contains blonanserin 10mg

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PUM

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Abstract

The invention discloses a [2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5, 6, 7, 8, 9, 10- hexahydro-cycloocta-(b) pyridine), a composition of salts thereof for medical purposes and a preparation method thereof. The pharmaceutical composition has such a stabilizing agent as alkaline substance with a weight not less than 10 percent. The composition has good stability and can block a 5-hydroxytryptamine-2 acceptor and a dopamine-2 acceptor and be applied to the treatment of schizophrenia.

Description

technical field [0001] The present invention relates to a compound containing Blonanserin (Blonanserin), chemical name [2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8, A pharmaceutical composition of 9,10-hexahydroaromatic octa[b]pyridine] and its pharmaceutically acceptable salts, especially a pharmaceutical composition containing weakly basic substances. Background technique [0002] Both serotonin and dopamine in the central nervous system play an important role in the development of human emotions and mental functions, and dysfunction of this system seems to be closely related to the development of mental disorders related to cerebrovascular diseases. [0003] For the chemotherapy of mental disorders associated with cerebrovascular diseases, it has been reported that dopamine-2 receptor blockers (a typical antipsychotic) are effective to some extent, but they can cause Patients with mood disorders, decreased spontaneity, etc. deteriorated, so the drug could not ac...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K47/02A61P25/00
Inventor 田瑞琴
Owner 北京德众万全医药科技有限公司
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