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Sustained release preparation of blonanserin and preparation method thereof

A blonanserin and slow-release technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as inconvenient use, side effects, "peaks and valleys", and achieve price Inexpensive, easy to take, and less side effects

Active Publication Date: 2015-01-28
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, ordinary tablets and powders often need to be administered several times a day, which is not only inconvenient to use, but also fluctuates greatly in blood drug concentration, with "peak and valley" phenomenon
When the blood concentration is high, side effects or even poisoning may occur; when the concentration is low, the therapeutically effective concentration may be lower, so that the curative effect cannot be shown

Method used

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  • Sustained release preparation of blonanserin and preparation method thereof
  • Sustained release preparation of blonanserin and preparation method thereof
  • Sustained release preparation of blonanserin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Prescription of sustained-release blonanserin pellets

[0022]

[0023] (2) Ordinary blonanserin pellet prescription

[0024]

[0025] Prepare the tablet mix recipe

[0026] component name

[0027] Compressed into 280 tablets.

[0028] According to the specific preparation method of the above prescription:

[0029] 1), based on the mass percentage of slow-release blonanserin components, weigh blonanserin, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, lactose, sugar powder, 17% starch slurry, and mix well , then add the prescribed amount of calcium hydrogen phosphate and magnesium stearate, continue to mix evenly, and add an appropriate amount of water to prepare a soft material;

[0030] 2), according to the mass percentage of ordinary granule blonanserin, weigh blonanserin, lactose, 17% starch slurry, mannitol, povidone, sodium carboxymethyl starch, and magnesium stearate. , adding blonanserin sustained-release granules, mixing un...

Embodiment 2

[0035] Prepare according to the prescription of embodiment 1 slow-release component and common component prescription, prepare the mixed prescription quantity of tablet

[0036] component name

Dosage (g)

Sustained-release blonanserin pellets

75.00

Ordinary blonanserin pellets

25.00

Total

100.00

[0037] Compressed into 280 tablets.

[0038] According to the specific preparation method of the above prescription:

[0039] 1), based on the mass percentage of slow-release blonanserin components, weigh blonanserin, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, lactose, sugar powder, 17% starch slurry, and mix well , then add the prescribed amount of calcium hydrogen phosphate and magnesium stearate, continue to mix evenly, and add an appropriate amount of water to prepare a soft material;

[0040]2), according to the mass percentage of ordinary granule blonanserin, weigh blonanserin, lactose, 17% starch slurry, m...

Embodiment 3

[0042] Prepare according to the prescription of embodiment 1 slow-release component and common component prescription, prepare the mixed prescription quantity of tablet

[0043] component name

Dosage (g)

Sustained-release blonanserin pellets

80.00

Ordinary blonanserin pellets

20.00

Total

100.00

[0044] Compressed into 280 tablets.

[0045] According to the specific preparation method of the above prescription:

[0046] 1), based on the mass percentage of slow-release blonanserin components, weigh blonanserin, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, lactose, sugar powder, 17% starch slurry, and mix well , then add the prescribed amount of calcium hydrogen phosphate and magnesium stearate, continue to mix evenly, and add an appropriate amount of water to prepare a soft material;

[0047] 2), according to the mass percentage of ordinary granule blonanserin, weigh blonanserin, lactose, 17% starch slurry, ...

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Abstract

The invention relates to a sustained release preparation of blonanserin and a preparation method of the sustained release preparation of the blonanserin. A blonanserin tablet is prepared by mixing slow release particles prepared by slow release components and common components according to the prescription proportion; the mass ratio of the slow release components to the common components ranges from 75:25 to 80:20; the slow release components of the blonanserin tablet mainly comprise, by mass, 8.00%-12.0% of the blonanserin, 15.0%-20.0% of hydroxypropyl methylcellulose, 15.0%-25.0% of sodium carboxymethylcellulose and the like; the common components mainly comprise, by mass, 8.00%-12.0% of the blonanserin, 30.0%-50.0% of lactose and the like. By means of the tablet prepared from the sustained release preparation, the number of medicine taking can be decreased, the stable blood concentration can be maintained, and side effects can be reduced.

Description

technical field [0001] The present invention relates to a medicine and a preparation method thereof, in particular to a blonanserin oral sustained-release preparation and a preparation method thereof. Background technique [0002] Schizophrenia is a serious, disabling mental illness. It has been more than 50 years since the first anti-schizophrenia drug, chlorpromazine, was clinically applied in 1953. Antipsychotic drugs commonly used in the market are divided into two categories according to their receptor blocking effects: typical and atypical: the former representative drugs are chlorpromazine and haloperidol, which mainly block dopamine receptors. The positive symptoms of the disease have better curative effect. But at the same time, extrapyramidal system reaction (ESP) is common, and the effect on negative symptoms is poor; the latter represents drugs such as risperidone, olanzapine, quetiapine and ziprasidone, etc., and the new generation of atypical antipsychotics a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/496A61K47/38A61K47/12
Inventor 马小玲周禹孔祥生谭伟
Owner LIVZON PHARM GRP INC
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