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External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof

A technology of sprays and eye drops, which is applied in the field of compound oil nanoemulsion sprays and eye drops for external use and its preparation, can solve the problems of increased pain, impact on vision and eye movement, and inaccurate dosage of patients, and achieve increased Targeting and adhesion, improving bioavailability, increasing the effect of drug absorption

Inactive Publication Date: 2009-10-14
陈亚玲 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical proof: using exposure and drying to control infection will damage the remaining appendages of the body, deepen the wound surface, easily form scabs, and dry and crack the surface, resulting in subscar infection; frequent and large doses of antibiotic ointment and silver sulfadiazine are prone to drug resistance Sexuality, leading to poor antibacterial and penetrability, affecting wound healing
On the other hand, the clinical use of sulfadiazine silver preparations found that the patient's pain increased significantly, and there were disadvantages such as slow desquamation, unsatisfactory healing, and excessive exudation.
Clinical practice has proved that large doses of antibiotics or external application of silver sulfadiazine to wounds may lead to superinfection of drug-resistant strains and fungi
[0004] Studies on the eye drops that have been on the market show that: due to the action of eyeball movement and the nasolacrimal system, a large amount of drugs are lost, multiple administrations are required every day, the dosage is inaccurate, and the concentration of drugs in the eyes fluctuates greatly; Or ointment administration and affect vision and eye movement
In order to overcome the above shortcomings, at present, the addition of hydrophilic gel carbomer (carbomer) is often used to increase the viscosity, delay the residence time of the drug, and increase absorption; but carbomer is easy to blur the vision and affect eyelid movement; or implant long-acting Controlled-release drug delivery system, such as Ocusert (pilocarpine controlled-release film), but the patient has a foreign body sensation

Method used

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  • External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof
  • External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof
  • External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, preparation composite oil nanoemulsion spray and eye drops

[0040] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 1 (made into 1000ml)

[0041] Table 1 The distribution ratio of each component of the composite oil nanoemulsion

[0042] component name

Weight percentage (%)

Feed amount (g)

effect

[0043] peppermint oil

0.1

1.0

Antibacterial anti-inflammatory

Soybean oil

9.9

99.0

Nutrients

egg yolk lecithin

1.2

12.0

Wetting agents, nutritional supplements,

carrier, emulsifier

1% NaOH

0.15

1.5

pH regulator

Glycerol

2.2

22.0

isotonicity regulator

Water for Injection

86.45

864.5

solvent

[0044] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0045] a) Weigh 1.0 g of peppermint oil (s...

Embodiment 2

[0054] Embodiment 2, preparation composite oil nanoemulsion spray and eye drops

[0055] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 2 (made into 1000ml).

[0056] Table 2 The distribution ratio of each component of the composite oil nanoemulsion

[0057] component name

weight ratio(%)

Feed amount (g)

effect

Curcuma Oil

0.5

5.0

Antibacterial anti-inflammatory

Soybean oil

9.5

95.0

Nutrients

egg yolk lecithin

1.5

15.0

Wetting agent, nutritional supplement

agent, carrier, emulsifier

1% NaOH

0.13

1.3

pH regulator

Glycerol

2.25

22.5

isotonicity regulator

Water for Injection

86.12

861.2

solvent

[0058] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0059] a) Weigh 5.0 g of zedoary oil (Zhejiang Tianrui Pharmace...

Embodiment 3

[0068] Embodiment 3, preparation composite oil nanoemulsion spray and eye drops

[0069] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 3 (made into 1000ml).

[0070] Table 3 The distribution ratio of each component of the composite oil nanoemulsion

[0071] component name

weight ratio(%)

Feed amount (g)

effect

Curcuma Oil

1.0

10.0

Antibacterial anti-inflammatory

castor oil

5.0

50.0

D

Soy lecithin

0.5

5.0

Wetting agent, nutritional supplement

agent, carrier, emulsifier

1% NaOH

0.18

1.8

Emulsifier, pH adjuster

Glycerol

1.5

15.0

isotonicity regulator

Water for Injection

91.82

918.2

solvent

[0072] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0073] a) Weigh 10.0 g of zedoary oil and 50.0 g of castor oil (Sha...

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Abstract

The invention discloses an external spraying agent and / or eye drop of compound oil nano-emulsion as well as preparation method thereof. The pH value of the spraying agent and / or eye drop is 3-9. The spraying agent and / or eye drop comprise the following components according to the weight portion: 5-15 of compound oil, 0.5-2.0 of phospholipid, 0.5-3.0 of propanetriol, sodium hydroxide and medicinal water, wherein the compound oil comprises the following components: (1) zedoary turmeric oil and / or peppermint oil, and (2) soybean oil and / or castor oil. The mass ratio of the (1) and the (2) in the compound oil is 1:99-30:70. The spraying agent of the compound oil nano-emulsion, which is prepared by the invention, is used for antibiosis, inflammation diminishing and wound healing in the process of curing burn and scald. The eye drop of the compound oil nano-emulsion is used for curing eye strain, xerophthalmia and eye inflammation.

Description

technical field [0001] The invention relates to a compound oil nanoemulsion spray and eye drops for external use and a preparation method thereof. Background technique [0002] According to statistics, the annual incidence rate of burns in my country is 2%, that is, about 22 million people suffer from burns of varying degrees every year. Plus various scald patients, a total of about 30 million patients need treatment. Most of the external burn medicines on the market are traditional Chinese medicine ointments, and there are also common sprays; chemical medicines include powders, lotions, and film-coating agents; products are mainly ointments and powders, and the overall dosage form structure is still quite backward. [0003] At present, there are still great disadvantages in the treatment of burns, and the treatment of large area burns is mostly followed by exposure and drying therapy. Clinical proof: using exposure and drying to control infection will damage the remaining...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K9/107A61K47/44A61P17/02A61P27/02A61K47/24
Inventor 陈亚玲傅磊杨雪
Owner 陈亚玲
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