External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof
A technology of sprays and eye drops, which is applied in the field of compound oil nanoemulsion sprays and eye drops for external use and its preparation, can solve the problems of increased pain, impact on vision and eye movement, and inaccurate dosage of patients, and achieve increased Targeting and adhesion, improving bioavailability, increasing the effect of drug absorption
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Embodiment 1
[0039] Embodiment 1, preparation composite oil nanoemulsion spray and eye drops
[0040] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 1 (made into 1000ml)
[0041] Table 1 The distribution ratio of each component of the composite oil nanoemulsion
[0042] component name
Weight percentage (%)
Feed amount (g)
effect
[0043] peppermint oil
0.1
1.0
Antibacterial anti-inflammatory
9.9
99.0
Nutrients
1.2
12.0
Wetting agents, nutritional supplements,
carrier, emulsifier
1% NaOH
0.15
1.5
pH regulator
2.2
22.0
isotonicity regulator
Water for Injection
86.45
864.5
[0044] (2) Preparation of composite oil nanoemulsion spray and eye drops
[0045] a) Weigh 1.0 g of peppermint oil (s...
Embodiment 2
[0054] Embodiment 2, preparation composite oil nanoemulsion spray and eye drops
[0055] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 2 (made into 1000ml).
[0056] Table 2 The distribution ratio of each component of the composite oil nanoemulsion
[0057] component name
weight ratio(%)
Feed amount (g)
effect
Curcuma Oil
0.5
5.0
Antibacterial anti-inflammatory
9.5
95.0
Nutrients
1.5
15.0
Wetting agent, nutritional supplement
agent, carrier, emulsifier
1% NaOH
0.13
1.3
pH regulator
2.25
22.5
isotonicity regulator
Water for Injection
86.12
861.2
[0058] (2) Preparation of composite oil nanoemulsion spray and eye drops
[0059] a) Weigh 5.0 g of zedoary oil (Zhejiang Tianrui Pharmace...
Embodiment 3
[0068] Embodiment 3, preparation composite oil nanoemulsion spray and eye drops
[0069] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 3 (made into 1000ml).
[0070] Table 3 The distribution ratio of each component of the composite oil nanoemulsion
[0071] component name
weight ratio(%)
Feed amount (g)
effect
Curcuma Oil
1.0
10.0
Antibacterial anti-inflammatory
5.0
50.0
D
0.5
5.0
Wetting agent, nutritional supplement
agent, carrier, emulsifier
1% NaOH
0.18
1.8
Emulsifier, pH adjuster
1.5
15.0
isotonicity regulator
Water for Injection
91.82
918.2
[0072] (2) Preparation of composite oil nanoemulsion spray and eye drops
[0073] a) Weigh 10.0 g of zedoary oil and 50.0 g of castor oil (Sha...
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