External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof

Abstract

The invention discloses an external spraying agent and/or eye drop of compound oil nano-emulsion as well as preparation method thereof. The pH value of the spraying agent and/or eye drop is 3-9. The spraying agent and/or eye drop comprise the following components according to the weight portion: 5-15 of compound oil, 0.5-2.0 of phospholipid, 0.5-3.0 of propanetriol, sodium hydroxide and medicinal water, wherein the compound oil comprises the following components: (1) zedoary turmeric oil and/or peppermint oil, and (2) soybean oil and/or castor oil. The mass ratio of the (1) and the (2) in the compound oil is 1:99-30:70. The spraying agent of the compound oil nano-emulsion, which is prepared by the invention, is used for antibiosis, inflammation diminishing and wound healing in the process of curing burn and scald. The eye drop of the compound oil nano-emulsion is used for curing eye strain, xerophthalmia and eye inflammation.

Description

technical field [0001] The invention relates to a compound oil nanoemulsion spray and eye drops for external use and a preparation method thereof. Background technique [0002] According to statistics, the annual incidence rate of burns in my country is 2%, that is, about 22 million people suffer from burns of varying degrees every year. Plus various scald patients, a total of about 30 million patients need treatment. Most of the external burn medicines on the market are traditional Chinese medicine ointments, and there are also common sprays; chemical medicines include powders, lotions, and film-coating agents; products are mainly ointments and powders, and the overall dosage form structure is still quite backward. [0003] At present, there are still great disadvantages in the treatment of burns, and the treatment of large area burns is mostly followed by exposure and drying therapy. Clinical proof: using exposure and drying to control infection will damage the remaining...

AI Technical Summary

Problems solved by technology

Clinical proof: using exposure and drying to control infection will damage the remaining appendages of the body, deepen the wound surface, easily form scabs, and dry and crack the surface, resulting in subscar infection; frequent and large doses of antibiotic ointment and silver sulfadiazine are prone to drug resistance Sexuality, leading to poor antibacterial and penetrability, affecting wound healing

On the other hand, the clinical use of sulfadiazine silver preparations found that the patient's pain increased significantly, and there were disadvantages such as slow desquamation, unsatisfactory healing, and excessive exudation.

Clinical practice has proved that large doses of antibiotics or external application of silver sulfadiazine to wounds may lead to superinfection of drug-resistant strains and fungi

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