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Application of iridoid compound to preparation of medicaments for curing benign prostatoplasia

A technology for iridoids and benign prostatic hyperplasia, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as toxic side effects, high prices, and influence on clinical and market promotion.

Active Publication Date: 2009-11-04
成都草木金华科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that it has a certain impact on a small number of cardiovascular patients, which limits the use of some elderly people and affects clinical and marketing promotion.
[0009] Most of the above-mentioned drugs have certain toxic and side effects, and the price is relatively high.

Method used

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  • Application of iridoid compound to preparation of medicaments for curing benign prostatoplasia
  • Application of iridoid compound to preparation of medicaments for curing benign prostatoplasia
  • Application of iridoid compound to preparation of medicaments for curing benign prostatoplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Preparation and structural identification of the compound of the present invention in embodiment 1

[0069] 1. Extraction and separation

[0070] The rhizome coarse powder (6kg) of S. chinensis was extracted by percolation with 95% ethanol as solvent, and 30 L of percolation liquid was collected, concentrated under reduced pressure to obtain 1500 g of total extract. The total extract was dispersed in 500ml of water, extracted successively with petroleum ether (60-90°C), ethyl acetate and n-butanol, and the solvent was recovered under reduced pressure to obtain 290g of petroleum ether (60-90°C) extract, extracted with ethyl acetate Product 130g, n-butanol extract 200g.

[0071] (1) further separation of petroleum ether extract

[0072] Petroleum ether (60-90°C) extract 100g was roughly divided into 204 parts by silica gel column chromatography (petroleum ether→petroleum ether / ethyl acetate→ethyl acetate→acetone gradient elution).

[0073] PE51 # ~65 # After the samp...

Embodiment 2

[0100] Embodiment 2 A preparation of capsules for resisting benign prostatic hyperplasia:

[0101] Take 1kg of compound A and 6kg of compound B, add an appropriate amount of starch, mix evenly, dry granulate, granulate and pack into capsules to obtain the product.

[0102] Prove the beneficial effect of the present invention by activity test below.

experiment example 2

[0106] Experimental Example 2 Compound B of the present invention (PE116 # ) inhibitory effect on 5α-reductase activity

[0107] The experimental method is the same as that of Experimental Example 1.

[0108]

[0109] The results show that sample PE116 # Shows positive with definite activity.

[0110] The above results showed that the petroleum ether part, the ethyl acetate part and the two monomer structures (compound A and compound B) significantly inhibited the formation of DHT.

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PUM

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Abstract

The invention discloses an application of an iridoid compound to the preparation of medicaments for curing benign prostatoplasia. The compound is prepared from valerianaceae plants with long medical history and good safety and further confirms pharmacodynamic materials than the prior jatamans valeriana rhizome plant extracts so that the preparation of new medicaments with favorable market prospects for curing the benign prostatoplasia is possible.

Description

technical field [0001] The invention relates to a new application of a class of compounds, in particular, the application of iridoid compounds in the preparation of medicines for treating benign prostatic hyperplasia, which belongs to the field of medicines. Background technique [0002] With the acceleration of the aging process of society, the incidence of many senile diseases is gradually increasing. Among them, male benign prostatic hyperplasia is one of the common diseases with a higher incidence rate. According to statistical analysis, benign prostatic hyperplasia (BPH) patients account for about 20% of elderly men. Its incidence also has a certain relationship with race and region. The incidence of oriental people is less than that of western people, and the incidence of BPH in foreign countries is significantly higher than that in China. Generally, the incidence rate is high in people with a family history of benign prostatic hyperplasia, accounting for more than 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P13/08
Inventor 肖丹边燕红
Owner 成都草木金华科技有限公司