Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of traditional Chinese medicine composition in preparing medicament for proliferating endothelial progenitor cells of peripheral blood of human body

An endothelial progenitor cell and composition technology, which is applied in the application field of traditional Chinese medicine, can solve the problems of abnormal vascular endothelial cell function, decreased cytokine response, and inability to effectively improve blood vessel development.

Active Publication Date: 2012-09-05
HEBEI YILING MEDICINE INST
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some cases, such as advanced age, diabetes, hypercholesterolemia, etc., the body's vascular development ability is impaired, not only the synthesis of endogenous vascular growth factors is reduced, but also the function of vascular endothelial cells is abnormal, and the response to cytokines Force also drops
Therefore, in the past, only vascular endothelial growth factor was given, which could not effectively improve the vascular development of these diseases, that is, in the treatment of tissue ischemic diseases, the curative effect of "therapeutic angiogenesis" (therapeutic angiogenesis) has reached its limit, which means Bringing new opportunities for "therapeutic vasculogenesis"

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of traditional Chinese medicine composition in preparing medicament for proliferating endothelial progenitor cells of peripheral blood of human body
  • Application of traditional Chinese medicine composition in preparing medicament for proliferating endothelial progenitor cells of peripheral blood of human body
  • Application of traditional Chinese medicine composition in preparing medicament for proliferating endothelial progenitor cells of peripheral blood of human body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the preparation of capsule

[0056] a) The raw material drug formula is:

[0057] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense (made) 13.2g

[0058] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpion 19.8g

[0059] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g;

[0060] b) Crushing process of medicinal materials:

[0061] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepar...

Embodiment 2

[0068] Embodiment 2: the preparation of tablet

[0069] a) The raw material drug formula is:

[0070] Ginseng 66g Leech 52.8g Wood Beetle 46.2g Frankincense (made) 13.2g

[0071] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpio 59.4g

[0072] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0073] b) Crushing process of medicinal materials:

[0074] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 70-90 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepared...

Embodiment 3

[0080] Embodiment 3: the preparation of pill

[0081] a) The raw material drug formula is:

[0082] Ginseng 39.6g Leech 66g Wood Beetle 46.2g Frankincense (made) 13.2g

[0083] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpion 46.2g

[0084] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0085] b) Crushing process of medicinal materials:

[0086] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powder after powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the powder is 10-20 μm;

[0087] c) Extraction concentration and drying process:

[0088] Add water to extract the volatile oil of Jiangxiang and sand...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparing a medicament for proliferating endothelial progenitor cells (EPCs) of peripheral blood of the human body. The traditional Chinese medicine composition can obviously improve the multiplication capacity of EPCs of the peripheral blood and has a relationship of time effect and dose effect within a certain concentration range.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition. Specifically, the invention relates to the application of a traditional Chinese medicine composition in the preparation of medicines for proliferating human peripheral blood endothelial progenitor cells, which belongs to the field of traditional Chinese medicine applications. Background technique [0002] Peripheral blood endothelial progenitor cells (hereinafter referred to as EPCs) are the precursor cells of vascular endothelial cells (hereinafter referred to as EC). After birth, EPCs exist in the bone marrow and can be transferred to the peripheral blood, where they participate in the vascular remodeling of ischemic tissues and the intima of blood vessels. It is not only involved in angiogenesis in human embryos, but also in the process of angiogenesis and endothelial injury repair after birth. [0003] Proliferation, chemotaxis and differentiation of EPCs der...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K9/08A61K9/10A61K9/20A61K9/48A61P9/10A61P43/00A61K31/045A61K35/62A61K35/64A61K35/646A61K35/648
Inventor 李向军安军永王超郑立发
Owner HEBEI YILING MEDICINE INST