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Preparation method of chonglou saponin I and application for inhibiting angiogenesis thereof

A technology of papaya saponin and glucopyranoside, applied in the field of inhibiting blood vessel growth, can solve the problems of hematopoietic system and immune function damage, patient death, etc., and achieve the effect of good blood vessel growth and broad application prospects

Inactive Publication Date: 2009-12-09
雷海民
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These treatments cause serious damage to the hematopoietic system and immune function of the human body, which can easily lead to the death of the patient.

Method used

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  • Preparation method of chonglou saponin I and application for inhibiting angiogenesis thereof
  • Preparation method of chonglou saponin I and application for inhibiting angiogenesis thereof
  • Preparation method of chonglou saponin I and application for inhibiting angiogenesis thereof

Examples

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Embodiment 1

[0015] Example 1 Saponin I of Pachyphyllum saponin (25R)-Δ5(6)-ene-spiroster-3-O-{α-L-arabinofuranosyl (1→4)}-[α-L-rhamnopyranose Preparation of glycosyl (1→2)]-3-O-β-D-glucopyranoside Take 2 kg of heavy building, and use 10 times the amount of petroleum ether, ethyl acetate, 95% ethanol, 80% ethanol, 60 % ethanol and water were ultrasonically extracted for 3 times, 30 min each time, after filtration, the supernatant was concentrated under reduced pressure to obtain various parts. The ethyl acetate extract was collected and eluted on a silica gel (200-300 mesh) column with petroleum ether first, and then with a mixture of petroleum ether, ethyl acetate and ethanol at a volume ratio of 1:1. The eluate obtained after elution with a mixture of petroleum ether, ethyl acetate and ethanol with a volume ratio of 1:1 was collected, concentrated under reduced pressure to obtain a crude product, which was further purified and crystallized by silica gel and reversed-phase silica gel to o...

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Abstract

The invention relates to a chonglou saponin I, namely, (25R)-Delta5(6)-alkene-spirost-3-O-{alpha-L- arabinofuranosyl (1->4)}-[alpha-L-rhamnopyranosyl (1->2)]-3-O-beta-D-glucopyranoside preparation method and an application for inhibiting angiogenesis thereof; the preparation method is composed of extracting polyphylla by using organic solvent and preparing chonglou saponin I by silica gel and reverse phase silica gel chromatography which can be used as an anti-neoplastic drug.

Description

technical field [0001] The present invention relates to a saponin I obtained by extracting and separating from Papaya papaya, that is, (25R)-Δ5(6)-ene-spiroster-3-O-{α-L-arabinofuranoside (1→4)} - the preparation method of [α-L-rhamnopyranosyl (1→2)]-3-O-β-D-glucopyranoside (CAS No. 76296-72-5), and its role in inhibiting blood vessels Uses for growth. Background technique [0002] Rhizoma Paridis, also known as Aescin, is a general term for plants of the genus Rhizoma Paridis in the family Liliaceae. There are 24 species of Pachyphylla plants in the world, and my country has the most species with 19 species, among which the species and resources in the southwestern provinces are extremely rich. Common varieties include Huazhonglou, Dianzhonglou and Aescin. The medicinal ones are Huachonglou, Yunnanchonglou, Aescinus chinensis, Narrowleaf Chonglou, Changyaogechonglou, Hainan Chonglou, Lingyun Chonglou, and Nanchonglou. It is recorded in the 2005 edition of "Chinese Pharm...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K31/7048A61P35/00
Inventor 毕葳雷海民李强
Owner 雷海民
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