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Application of Chinese violet in resisting diabetes mellitus and preventing relative metabolic diseases

A technology for metabolic diseases, Radix Viola

Inactive Publication Date: 2009-12-16
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main side effects of this class of drugs are edema and weight gain

Method used

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  • Application of Chinese violet in resisting diabetes mellitus and preventing relative metabolic diseases
  • Application of Chinese violet in resisting diabetes mellitus and preventing relative metabolic diseases
  • Application of Chinese violet in resisting diabetes mellitus and preventing relative metabolic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1. Preparation of Viola Viola Extract

[0048] 1kg of dried Viola dichotoma was extracted twice with 10 times the amount of water, 2 hours each time, the combined extract was placed at room temperature, the extract was passed through the treated macroporous resin column, eluted with water, and then eluted with 30% ethanol. The eluate was concentrated under reduced pressure to obtain 30 g of the effective fraction.

[0049] Pharmacological experiment

experiment example 1

[0050] Experimental Example 1. Effect of Viola Didin Extract on Blood Glucose Levels in Type 1 Diabetic Mice

[0051] method:

[0052] Normal male ICR mice, weighing 24-26g, were injected with 70mg / kg of alloxan into the tail vein. Blood glucose levels were measured by the glucose oxidase method. Animals whose blood glucose level exceeded 200 mg / dl after 72 hours were selected as type 1 diabetes model mice.

[0053] 30 diabetic mice were randomly divided into 4 groups according to the blood sugar level: the control group, metformin, viola 1 and viola 2 groups, and the same volume of water, metformin 200mg / kg, viola 1g / kg (equivalent to crude drug 4.5g / kg) and violadin 2g / kg (equivalent to crude drug 9.1g / kg) for intragastric administration. After administration for 9 consecutive days, the animal's blood glucose (equivalent to postprandial blood glucose) in the morning (8:30am) and blood glucose (equivalent to fasting blood glucose) after fasting for 2 hours were measured. ...

experiment example 2

[0056] Experimental Example 2. Effect of Viola Didin Extract on Oral Glucose Tolerance in Type 1 Diabetic Mice

[0057] method:

[0058] Normal male ICR mice, weighing 24-26g, were injected with 70mg / kg of alloxan into the tail vein. Blood glucose levels were measured by the glucose oxidase method. Animals whose blood glucose level exceeded 200 mg / dl after 72 hours were selected as type 1 diabetes model mice.

[0059] 30 diabetic mice were randomly divided into 4 groups according to the blood sugar level: the control group, metformin, viola 1 and viola 2 groups, and the same volume of water, metformin 200mg / kg, viola 1g / kg (equivalent to crude drug 4.5g / kg) and violadin 2g / kg (equivalent to crude drug 9.1g / kg) for intragastric administration. Continuous administration for 14 days. Glucose 2g / kg was administered to the animals, and the blood glucose levels were measured at 0, 30, 60, and 120 minutes after the glucose load, and the area under the blood glucose-time curve (A...

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Abstract

The invention discloses application of Chinese violet in resisting diabetes mellitus and preventing relative metabolic diseases, in particular extract and effective parts of viola yedoensis makino, a preparation method of the extract and the effective parts, a medicine composition containing the extract or effective parts of the Chinese violet, and application of products for preventing diabetes mellitus and relative metabolic diseases.

Description

technical field [0001] The present invention relates to Viola Yedoensis Makino extract and effective parts; preparation method of the extract and effective parts; pharmaceutical composition containing Viola Yedoensis Makino extract or effective parts; The use of metabolic disease products belongs to the technical field of medicine. Background technique [0002] Diabetes is a chronic metabolic disease characterized by elevated blood sugar, mainly divided into insulin-dependent type 1 diabetes and non-insulin-dependent type 2 diabetes. Impaired glucose tolerance refers to the body's reduced tolerance to glucose. Insulin resistance refers to the reduced sensitivity and / or responsiveness of the body to insulin, which is the common pathophysiological basis of diabetes-related metabolic diseases, and is related to impaired glucose tolerance / type 2 diabetes and its complications, obesity, Clinical abnormalities such as dyslipidemia, non-alcoholic fatty liver disease, and coronary...

Claims

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Application Information

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IPC IPC(8): A61K36/86A23L1/29A61P3/10A23L33/00
Inventor 叶菲张东明田金英吴倩杨敬芝丛维娜刘倩陶荣亚牛亚景左丽
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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