Biodegradable shape-memory material based on D,L-polylactic acid and preparation method thereof

A memory material, polylactic acid technology, applied in the field of biomedical polymer materials, can solve the problems of low deformation rate, non-biodegradable, high deformation recovery temperature, etc., and achieve the effect of good biodegradability and good biocompatibility

Inactive Publication Date: 2009-12-16
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of these two materials in the biomedical field has its limitations, such as high deformation recovery temperature, low deformation rate, and non-biodegradable, etc.

Method used

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  • Biodegradable shape-memory material based on D,L-polylactic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Accurately weigh recrystallized D, L-lactide 14.4g (0.1mol), butanediol 0.887ml (0.01mol) and stannous octoate 0.0083g (2 × 10 -5 mol), mixed evenly, reacted in vacuum, and reacted at 140°C for 24 hours. The reactant was dissolved in chloroform, precipitated with ethanol, and dried in vacuum to constant weight to obtain hydroxyl-terminated D, L-polylactic acid. The molecular weight calculated by proton nuclear magnetic resonance spectrum is 1834, and the glass transition temperature T g = 14.27°C.

Embodiment 2

[0022] Embodiment 2: Accurately weigh recrystallized D, L-lactide 14.4g (0.1mol), butanediol 0.355ml (0.004mol) and stannous octoate 0.0083g (2 × 10 -5 mol), mixed evenly, reacted in vacuum, and reacted at 140°C for 24 hours. The reactant was dissolved in chloroform, precipitated with ethanol, and dried in vacuum to constant weight to obtain hydroxyl-terminated D, L-polylactic acid. The molecular weight calculated by proton nuclear magnetic resonance spectrum is 3720, and the glass transition temperature T g = 36.33°C.

Embodiment 3

[0023] Embodiment 3: Accurately weigh recrystallized D, L-lactide 14.4g (0.1mol), butanediol 0.177ml (0.002mol) and stannous octoate 0.0083g (2 × 10 -5 mol), mixed evenly, reacted in vacuum, and reacted at 140°C for 24 hours. The reactant was dissolved in chloroform, precipitated with ethanol, and dried in vacuum to constant weight to obtain hydroxyl-terminated D, L-polylactic acid. The molecular weight calculated by proton nuclear magnetic resonance spectrum is 7434, and the glass transition temperature T g = 45.02°C.

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Abstract

The invention provides a biodegradable shape-memory material based on D,L-polylactic acid and a preparation method thereof. The shape-memory material is characterized in that: terminal hydroxy D,L-polylactic acid (PDLLA) is used as a soft segment; a carbamido chain segment formed by diisocyanate and reactive hydrogen-containing bifunctional small molecule diamine is used as a hard segment; and when a shape-memory temperature is between 30 and 60 DEG C and a deformation rate is about 300 percent, a shape fixed rate is between 96 and 100 percent and a shape recovery rate is between 94 and 100 percent. The shape-memory material has the excellent characteristics of strong deformation retentivity, high recovery rate and good memory repeatability, and simultaneously has biodegradability and property controllability. A recovery temperature is controlled to the vicinity of a body temperature by adjusting compositions of a polymer. The biodegradable shape-memory material has an important application value in the aspects of surgical minimally invasive surgery and an implant body material of a medical appliance.

Description

technical field [0001] The invention relates to a shape memory material based on D, L-polylactic acid and a preparation method thereof, belonging to the field of biomedical polymer materials. Background technique [0002] Shape memory materials refer to intelligent materials that can perceive the stimuli of environmental changes (temperature, light, force, electricity, and magnetism), and respond to such changes, adjust their mechanical parameters, and return to their preset states. The current shape memory materials mainly include shape memory alloys, memory ceramics and memory polymer materials. Among them, alloy and ceramic memory materials were discovered the earliest and most widely used. However, the application of these two materials in the biomedical field has its limitations, such as high deformation recovery temperature, low deformation rate, and non-biodegradable. In contrast, shape memory polymers not only have a large amount of deformation, are easy to process...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/42C08G63/08
Inventor 王远亮李永刚罗彦凤魏小娅胡承波阮长顺黄美娜
Owner CHONGQING UNIV
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