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Method for preparing medicinal sterile sodium bicarbonate raw powder

A technology of sodium bicarbonate and raw powder, which is applied in the field of preparation of pharmaceutical raw materials, can solve the problems of difficult control of content, low pass rate, and high cost, and achieve the effects of low production cost, stable product quality, and qualified quality

Inactive Publication Date: 2009-12-30
HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because industrialized production sodium bicarbonate is to spray dry with spray tower, its equipment is huge, and energy consumption is big, and cost is easy to be high, is difficult for producing in pharmaceutical enterprise; Another recrystallization method, but its content is difficult for control, and qualified rate is low (bicarbonate Sodium aqueous solution is unstable, easily decomposes at room temperature, and partly turns into carbonate, causing its content to be unqualified), and consumes a large amount of solvent, and the cost is also very high, so it cannot be applied to production

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0018] Weigh 30 grams of industrial sodium carbonate, at room temperature, add 250 ml of purified water to dissolve to a concentration of 12%, pass carbon dioxide under stirring for about 1 hour, until the solution pH is about 7.8, add 95% ethanol dropwise to the solution within 1 hour 300 milliliters, until the crystals are separated out, grow the crystals at 15° C. for 1 hour, filter, and vacuum-dry at 30° C. for 6 hours until the moisture content is qualified (≤0.3%) to obtain 39 grams of the product, the content is 99.9%, and the yield is 130.0%.

Embodiment 2

[0020] Weigh 30 grams of industrial sodium carbonate, at room temperature, add 200 ml of purified water to dissolve to a concentration of 15%, pass carbon dioxide under stirring for about 1 hour, until the solution pH is about 7.8, add 95% ethanol dropwise to the solution within 1 hour 300 milliliters, until the crystals are separated out, grow the crystals at 15° C. for 1 hour, filter, and vacuum-dry at 30° C. for 6 hours until the moisture content is qualified (≤0.3%) to obtain 39 grams of the product, the content is 99.9%, and the yield is 130.0%.

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Abstract

The invention relates to a method for preparing medicinal sterile sodium bicarbonate raw powder, which comprises the following steps: (1) subjecting industrial sodium carbonate serving as a raw material to purification, dissolution in water, decarburization and membrane filtration; (2) introducing industrial carbon dioxide gas subjected to membrane treatment into solution of sterile sodium bicarbonate to carry out acidification, and controlling parameters such as flow rate, reaction time, terminal pH value and stirring speed; (3) adding ethanol liquid subjected to membrane treatment into solution in which reaction is finished to allow sodium bicarbonate crystals to precipitate gradually, adjusting stirring speed, and controlling crystallization time to allow the crystallization to be completed fully; and (4) filtering the solution by a crystal filter to obtain the product, and drying the product by using a vibratory drying machine to obtain a finished product that meets medicinal standards.

Description

technical field [0001] The invention relates to a method for preparing medicinal raw materials, in particular to a method for preparing medicinal sterile sodium bicarbonate raw powder. Background technique [0002] Sodium bicarbonate is usually used as a source of carbon dioxide in effervescent tablets and effervescent granules in pharmaceutical preparations. It is also widely used in preparations to generate or maintain alkaline pH values. Currently, many cephalosporin antibiotics are used in minute injection preparations Mix this product (must use sterile original powder) as a buffer and co-solvent. [0003] Because industrialized production sodium bicarbonate is to spray dry with spray tower, its equipment is huge, and energy consumption is big, and cost is easy to be high, is difficult for producing in pharmaceutical enterprise; Another recrystallization method, but its content is difficult for control, and qualified rate is low (bicarbonate Sodium aqueous solution is u...

Claims

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Application Information

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IPC IPC(8): C01D7/10
Inventor 马杰赵玉新景士云黄宇鸿邹国利刘勇范一楠刘丹
Owner HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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