Pulse-activating preparation for injection and preparation method thereof

Abstract

The invention relates to a pulse-activating preparation for injection and a preparation method thereof. The pulse-activating preparation contains red ginseng, ophiopogon root and Chinese magnoliavine fruit and is mainly used for treating deficiency of both qi and yin, cardiopalmus caused by feeble pulse, breath shortage, cold limbs, sweating, feeble and impalpable pulse, myocardial infraction, cardiogenic shock and infectious shock. The invention has more stable preparation quality and simple and convenient preparation processes, is safe and reliable, and provides the reasonable and realisticpreparation method for large-scale production of Chinese injection preparation.

Description

technical field [0001] The technology of the invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method for making injection preparations from natural medicine extracts of traditional Chinese medicines. Background technique [0002] Shengmaisan prescription (ginseng, Ophiopogon japonicus, Schisandra chinensis) is derived from "Internal and Internal Injury Debate Theory of Stomach Qi Injury due to Heatstroke in Juan". Traditional Chinese medicine Shengmaisan is used for critically ill patients, which is beneficial to Qi solidification and strengthens the heart. The clinical application effect is better. [0003] Shengmai Injection is an intravenous injection made according to the traditional ancient prescription Shengmai Powder through formulation reformation. It has the effect of replenishing qi and nourishing yin, recovering pulse and solidifying the pulse. It is used for palpitations, shortness of breath, col...

AI Technical Summary

Problems solved by technology

[0011] Clinical reactions, a small number of traditional Chinese medicine injections have problems such as unstable quality and allergic reactions. This is because the injections are generally obtained after extraction, simple refining, liquid filling, sealing and sterilization. Chinese herbal extracts contain a large number of impurities such as tannin Acids, pigments, bacterial heat sources, etc. are the key issues restricting the improvement of the quality and stability of traditional Chinese medicines, which directly affect the quality and clinical efficacy of products.

Many inventors and pharmaceutical companies have done a lot of research work, such as patent application number 200510047834.9, which discloses a large-capacity injection of Shengmai and its preparation method. Effective extraction and purification methods are not disclosed in this method, so it is difficult to guarantee Product quality, and it is difficult to achieve in large-scale production; the patent application number is 200810101610.5, which discloses a Sanwei Shengmai injection and its preparation method. Although ultrafiltration technology is used in this method, the key control of ultrafiltration technology is not proposed It is difficult to operate in large-scale production, and macroporous resin adsorption technology is applied in the extraction of red ginseng. Although macroporous resin is an effective purification method for enriching active ingredients and removing impurities, its porogens and degradation products Toxic, on November 28, 2000, the National Center for Drug Evaluation held a "Macroporous Adsorption Resin Separation and Purification Technology Symposium", the meeting pointed out that Chinese medicine injections should be used with caution when using macroporous resins for purification, and sufficient evidence needs to be provided. Therefore, this method is operable in the laboratory, but it is rarely used in the actual large-scale industrial production of injections.

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