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Bio-medical pressure-sensitive adhesive (PSA) and preparation method thereof

A biomedical and pressure-sensitive adhesive technology, applied in the fields of application, medical science, surgery, etc., can solve the problems of poor air permeability, water absorption and oxygen permeability, skin maceration, residue, etc., to improve dispersion performance and Good stability, water absorption and air permeability, good biocompatibility effect

Inactive Publication Date: 2013-06-05
武汉市思泰利医疗器械发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the traditional pressure-sensitive adhesive's adhesiveness decreases when it adheres in a humid environment or on a water-containing surface, some will have residues, and the compatibility with the skin is not good enough, and the air permeability, water absorption and oxygen permeability Poor performance, when it is attached to the skin for a long time, it will produce water accumulation, the skin will be macerated or even whitened, and it will cause damage to the skin, so the prepared product has good air permeability, good biocompatibility, and no sensitization. , no residue, and a biomedical pressure-sensitive adhesive with strong adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: get the SiO that particle size is 30nm 2 The particles self-assemble with polylysine. Dissolve 40g of polylysine with a number average molecular weight of about 8000 in 3000g of water, stir with a magnetic stirrer at a speed of 1000r / min for half an hour, adjust the pH to 9-10 with 1mol / L NaOH solution, and add while adding Stirring, then 80g of nano-SiO with a particle size of 30nm 2 Add the particles into the above solution, continue to stir with a magnetic stirrer at a speed of 400r / min for half an hour, and keep the pH at 9-11. Let it stand at room temperature for 2 hours, then centrifuge it, wash it, and dry it in an oven at 50°C for 24 hours to prepare polylysine-modified nano-SiO 2 particle.

Embodiment 2

[0016] Embodiment 2: get the SiO that particle size is 20nm 2 The particles self-assemble with poly-L-glutamic acid. Dissolve 45g of poly-L-glutamic acid with a number average molecular weight of about 9000 in 4000g of water, stir with a magnetic stirrer at a speed of 1000r / min for 30 minutes, then stir 50g of the particle size at a low speed of 400r / min. 30nm nano-SiO 2 Add the particles into the above solution, continue to stir at a low speed for 10 minutes, let stand at room temperature for 2 hours, then stand at 80°C for 20 hours, centrifuge the obtained white precipitate, wash it, and dry it in an oven at 50°C for 24 hours to obtain the poly L-glutamic acid modified nano-SiO 2 particle.

Embodiment 3

[0017] Embodiment 3: get the SiO that particle size is 40nm 2 Particles self-assemble with polyaspartic acid induced by evaporation. Dissolve 25g of polyaspartic acid with a number average molecular weight of about 5000 in 2000ml of water at room temperature, and add 44g of nano-SiO with a particle size of 30nm under the condition of constant stirring with a magnetic stirrer at a speed of 1000r / min. 2 Particles, then stirred at a low speed of 400r / min for 1h, and then the above solution was left at room temperature for 2h, centrifuged, washed, and dried in an oven at 50°C for 24 hours, and the obtained solid product was polyaspartic acid modified nano-SiO 2 particle.

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PUM

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Abstract

The invention relates to a bio-medical pressure-sensitive adhesive (PSA) which comprises the components by weight percent: 30-50% of polyisobutene, 37-55% of plant polysaccharide and 1-15% of polyamino acid modified nano SiO2. A preparation method of the PSA comprises: according to the weight ratio of 30-50% of polyisobutene, 37-55% of plant polysaccharide and 1-15% of polyamino acid modified nano SiO2, firstly putting the polyisobutene and the plant polysaccharide into an open mill to be mixed and refined for 30-40min, and then adding the polyamino acid modified nano SiO2 particles into the mixture for continuously mixing and refining for 15-25min to lead dispersion to be uniform; after that, hot-pressing an adhesive layer with the needed thickness by a flat vulcanizing machine under theconditions that the vulcanization temperature is 60 DEG C, the vulcanization time is 3s, and the vulcanization pressure intensity is 5MPa. The prepared bio-medical pressure-sensitive adhesive has good stability, water absorptivity, air permeability and biocompatibility, no sensitization and residue, and very strong permanent adhesion.

Description

technical field [0001] The invention relates to a biomedical pressure-sensitive adhesive and a preparation process thereof, belonging to the technical field of biomedical pressure-sensitive adhesives. The biomedical pressure-sensitive adhesive has good stickiness, hydrophilicity, no residue, good biocompatibility with the skin, no allergens, good air permeability, and biodegradability. Background technique [0002] Pressure-sensitive adhesives have always been a hot topic in the field of medical patches. The correct selection of pressure-sensitive adhesives is the main factor related to the success or failure of product applications. In recent decades, the types of medical pressure-sensitive adhesives have developed rapidly, and new types of medical pressure-sensitive adhesives such as acrylic esters, silicone rubbers, and polyurethanes continue to emerge. Medical pressure-sensitive adhesives have high performance requirements, and they must meet: ①Good adhesion to various ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/02
Inventor 聂正稳胡红利汪波
Owner 武汉市思泰利医疗器械发展有限公司