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Preparation method and medicinal application of tanshinol

A technology of danshensu and pore size, which is applied in the field of medicine, can solve the problems of cumbersome operation and engineering, low yield of danshensu, and reduced efficacy of danshensu

Active Publication Date: 2010-01-27
贵州拜特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past, there were many shortcomings in the extraction process of Danshensu, the active ingredient in Danshen preparations, resulting in a very low yield of Danshensu, especially in the process of extraction, concentration, and drying. many
Traditional extraction of danshensu mostly uses water as the extraction solvent. Although it is suitable for industrial production, and the cost is low, it is easy to realize, and the environmental pollution is small, but the danshensu extracted with water as a solvent contains many impurities, which reduces the efficacy of danshensu.
The patent application number is 01126883.2. Water is used as the extraction solvent, and impurities are removed by adsorption methods such as resin or ion exchange resin. Although the extraction rate is high, the operation is cumbersome and the stability is poor, so it is not suitable for industrial production.
The patent application number is 200410021414.9. The Danshensu obtained by extracting is filtered with an ultrafiltration membrane to remove macromolecular substances. It still needs to be separated by normal phase chromatography, which is not suitable for industrialization.

Method used

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  • Preparation method and medicinal application of tanshinol
  • Preparation method and medicinal application of tanshinol
  • Preparation method and medicinal application of tanshinol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 300g of Danshen medicinal material, add 8 times the weight of the medicinal material in water, heat and extract at 100°C for 3 times, each time for 1.5 hours, filter, combine the three extracts, pour the extract into an inorganic ceramic membrane filter with a pore size of 0.44 microns. For primary filtration, the temperature in the container is 40°C, the filtration pressure is 0.1mpa, and the membrane surface flow rate is 4.0m / s. ℃, filtration pressure 0.15mpa, membrane surface flow velocity 4.0m / s, ultrafiltration is completed; the solution after ultrafiltration is transferred to an inorganic ceramic membrane with a pore size of 0.16 microns for nanofiltration, the temperature in the container is 80 ℃, and the filtration pressure is 0.5mpa. The membrane surface velocity is 3.0m / s, and the nanofiltration is completed; the nanofiltration solution is poured into the concentrator, the temperature is 70°C, the pressure is -0.05mpa, and concentrated, the density of the ...

Embodiment 2

[0019] Take 500g of Danshen medicinal material, add water 10 times the weight of the medicinal material, heat and extract at 100°C for 3 times, each time for 2 hours, filter, combine the three extracts, pour the extract into an inorganic ceramic membrane filter with a pore size of 0.44 microns for For primary filtration, the temperature in the container is 50°C, the filtration pressure is 0.3mpa, and the membrane surface flow rate is 6.0m / s. ℃, filtration pressure 0.25mpa, membrane surface flow velocity 5.0m / s, ultrafiltration is completed; the solution after ultrafiltration is transferred to an inorganic ceramic membrane with a pore size of 0.16 microns for nanofiltration, the temperature in the container is 90 ℃, and the filtration pressure is 1.5mpa. The membrane surface flow velocity is 4.0m / s, and the nanofiltration is completed; the nanofiltration solution is poured into the concentrator, the temperature is 90°C, the pressure is -0.15mpa, and concentrated, the density of ...

Embodiment 3

[0021] Take 400g of Danshen medicinal material, add 9 times the weight of the medicinal material in water, heat and extract at 100°C for 3 times, each time for 1.8 hours, filter, combine the three extracts, and pour the extract into an inorganic ceramic membrane filter with a pore size of 0.44 microns for further extraction. Primary filtration, the temperature in the container is 45°C, the filtration pressure is 0.2mpa, the membrane surface flow rate is 5.0m / s, and the primary filtration is completed; the filtrate after the primary filtration is poured into an inorganic ceramic membrane with a pore size of 0.22 microns for ultrafiltration, and the temperature in the container is 75 ℃, filtration pressure 0.20mpa, membrane surface flow velocity 4.5m / s, ultrafiltration is completed; the solution after ultrafiltration is transferred to an inorganic ceramic membrane with a pore size of 0.16 microns for nanofiltration, the temperature in the container is 85 ℃, and the filtration pres...

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PUM

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Abstract

The invention discloses a preparation method and a medicinal application of tanshinol. According to a great amount of experimental research, three inorganic ceramic membranes with different apertures and specifications are adopted in a tanshinol-extracting process to extract, separate and filter active ingredients by primary filtration, hyperfiltration and nanofiltration; experimental results show that the preparation method remarkably improves the content of the tanshinol as an active ingredient and reaches the yield larger than 82 percent; and animal experiments show that the tanshinol extracted by the preparation method has a remarkable pharmacological action.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of danshensu and its medical application. Background technique [0002] Cardiovascular and cerebrovascular diseases are a common disease that seriously threatens human beings, especially the health of middle-aged and elderly people over 50 years old. At present, even if the most advanced and perfect treatment methods are applied, more than 50% of cardiovascular and cerebrovascular patients cannot fully take care of themselves. The number of people who die from cardiovascular and cerebrovascular diseases in the world is as high as 15 million every year, ranking first among various causes of death. In my country alone, 3 million people die from cardiovascular and cerebrovascular diseases every year. Cardiovascular and cerebrovascular diseases have become the number one cause of death in humans. killer. According to the latest medical data, the inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/52C07C51/42A61K31/192A61P9/00
Inventor 朱岳兴伍朝平
Owner 贵州拜特制药有限公司