Point-and-click temperature/pH-sensibility microgel

Abstract

The invention provides a chemical approach which can adopt point-and-click chemistry to realize functional grouping on the bodies or the surfaces of high molecular hydrogel particles. The high molecular hydrogel particles are generally formed by the cross linking of a hydrophilic monomer and a functional group monomer. The invention mainly puts forward a point-and-click functional group which can be introduced by adopting a copolymerization mode and can carry out a 1,3-dipolar cycloaddition reaction of triazo-end alkynyl catalyzed by Cu (I). Simultaneously, a point-and-click reaction catalyzed by the Cu (I) and a coupling reaction of carboxyl-primary amine radicals initiated by 1-(3-dimethylin propyl)-3-ethyl carbon diimine hydrochloride are carried out in a water phase, are not disturbed mutually and are mutually orthogonal. The characteristic can be beneficial to the multi-function grouping of the microgel simultaneously. The temperature / pH-sensibility microgel containing the point-and-click functional group has potential application value in the aspects of targeting medicine release, molecular treatment, chemical / biologic sensors, water treatment and the like.

Description

technical field [0001] The invention belongs to the field of macromolecular synthesis chemistry, and in particular relates to a temperature / pH-sensitive and clickable macromolecular microgel formed by free radical polymerization in an aqueous phase, which facilitates the multifunctionalization of the microgel. It has potential application value in targeted drug release, biological / chemical sensors, multifunctional thin films, etc. Background technique [0002] Macromolecule micro-hydrogel (microgel) or hydrogel microparticles (hydrogelmicroparticles) is a kind of water-swellable cross-linked polymer particles of nanometer to micrometer scale. As early as 1935, Staudinger et al. synthesized a styrene-based polymer microgel. At this time, the swelling agent was an organic solvent such as benzene or toluene, which can be called an organic microgel (organo-microgel). (Staudinger, H.et al.Ber.1935, 67, 1164) In 1949, Baker first proposed the term microgel (microgel), especially ...

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Problems solved by technology

(Sharpless K.B.et al., Angew.Chem.Int.Ed.2002, 41, 2596) So far, there is no report on the combination of click chemistry and NIPAm-based polymer microhydrogels. The introduction of click chemistry into microhydrogels creates a favorable reaction environment for simultaneous multifunctionalization

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