Point-and-click temperature/pH-sensibility microgel

A Microgel, Sensitive Technology for Applications in Polymer Synthetic Chemistry

Inactive Publication Date: 2010-01-27
孟智平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Sharpless K.B.et al., Angew.Chem.Int.Ed.2002, 41, 2596) So far, there is no report on the combination of click chemistry and NIPAm-based polymer mic

Method used

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  • Point-and-click temperature/pH-sensibility microgel
  • Point-and-click temperature/pH-sensibility microgel
  • Point-and-click temperature/pH-sensibility microgel

Examples

Experimental program
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Effect test

example 1

[0034]First, weigh out 1.6 g of N-isopropylacrylamide (NIPAm), 200 microliters of acrylic acid (AAc), and 0.04 g of N,N-methylenebisacrylamide (BIS) with an analytical balance, and use 60 ml of deionized water Dissolve in a 200ml beaker, and if necessary, ultrasonically vibrate for 30 seconds to speed up the dissolution process. The above solution was then transferred into a 250 mL three necked round bottom flask via a syringe with a 0.8 micron pore size filter. The beaker was rinsed with an additional 30 mL of deionized water and sonicated, and the rinsed solution was transferred into a 250 mL three-neck round bottom flask through a 0.8 micron filter syringe. At this time, the flask was set in a silicone oil bath, nitrogen gas was introduced into the left bottle mouth, a thermometer was inserted into the right bottle mouth, and a condenser tube with a nitrogen outlet was connected to the middle bottle mouth, which was fixed on an iron stand. The temperature of the silicone o...

example 2

[0036] First, 1.6 grams of N-isopropylacrylamide (NIPAm), 200 microliters of acrylic acid (AAc), and 0.04 grams of N,N'-methylenebisacrylamide (BIS) were weighed out with an analytical balance, and 60 milliliters of deionized Dissolve water in a 200ml beaker, and if necessary, use a sonicator to sonicate for 30 seconds to speed up the dissolution process. The above solution was then transferred into a 250 mL three necked round bottom flask via a syringe with a 0.8 micron pore size filter. The beaker was rinsed with an additional 30 mL of deionized water and sonicated, and the rinsed solution was transferred into a 250 mL three-neck round bottom flask through a 0.8 micron filter syringe. At this time, the flask was set in a silicone oil bath, nitrogen gas was introduced into the left bottle mouth, a thermometer was inserted into the right bottle mouth, and a condenser tube with a nitrogen outlet was connected to the middle bottle mouth, which was fixed on an iron stand. The te...

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Abstract

The invention provides a chemical approach which can adopt point-and-click chemistry to realize functional grouping on the bodies or the surfaces of high molecular hydrogel particles. The high molecular hydrogel particles are generally formed by the cross linking of a hydrophilic monomer and a functional group monomer. The invention mainly puts forward a point-and-click functional group which can be introduced by adopting a copolymerization mode and can carry out a 1,3-dipolar cycloaddition reaction of triazo-end alkynyl catalyzed by Cu (I). Simultaneously, a point-and-click reaction catalyzed by the Cu (I) and a coupling reaction of carboxyl-primary amine radicals initiated by 1-(3-dimethylin propyl)-3-ethyl carbon diimine hydrochloride are carried out in a water phase, are not disturbed mutually and are mutually orthogonal. The characteristic can be beneficial to the multi-function grouping of the microgel simultaneously. The temperature/pH-sensibility microgel containing the point-and-click functional group has potential application value in the aspects of targeting medicine release, molecular treatment, chemical/biologic sensors, water treatment and the like.

Description

technical field [0001] The invention belongs to the field of macromolecular synthesis chemistry, and in particular relates to a temperature / pH-sensitive and clickable macromolecular microgel formed by free radical polymerization in an aqueous phase, which facilitates the multifunctionalization of the microgel. It has potential application value in targeted drug release, biological / chemical sensors, multifunctional thin films, etc. Background technique [0002] Macromolecule micro-hydrogel (microgel) or hydrogel microparticles (hydrogelmicroparticles) is a kind of water-swellable cross-linked polymer particles of nanometer to micrometer scale. As early as 1935, Staudinger et al. synthesized a styrene-based polymer microgel. At this time, the swelling agent was an organic solvent such as benzene or toluene, which can be called an organic microgel (organo-microgel). (Staudinger, H.et al.Ber.1935, 67, 1164) In 1949, Baker first proposed the term microgel (microgel), especially ...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F220/06C08F226/06
Inventor 孟智勇孟智平
Owner 孟智平
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