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Method for extracting succinic acid from fermentation liquor

A technology for succinic acid and fermentation broth, which is applied in the fields of carboxylate preparation, organic chemistry, etc., can solve the problems of high requirements for fermentation strains, poor performance of succinic acid-producing strains, unsuitable for industrial production, etc. Environmental pollution, reducing the consumption of auxiliary materials, and good product quality

Active Publication Date: 2010-02-10
ANHUI BBCA FERMENTATION TECH ENG RES
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  • Abstract
  • Description
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Problems solved by technology

[0005] However, this method has high requirements for fermentation strains, and is only suitable for the fermentation process of adding calcium salts to adjust the pH value during the fermentation process. The currently known succinic acid producing strains have poor performance in this regard and are not suitable for industrial production.

Method used

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Examples

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Effect test

Embodiment 1

[0027] The method for extracting succinic acid from fermented liquid comprises the steps:

[0028] 1. First, 2 cubic meters of succinic acid concentration is 6% succinic acid fermented liquid 70 ℃ with molecular weight cut-off is the ceramic membrane filtration of 150KD, obtains 2.15 cubic meters of concentration and is 5.5% supernatant.

[0029] 2. The succinate solution with a concentration of 5.5% reacts with calcium chloride at 40°C to form calcium succinate precipitates.

[0030] 3. Separate the reaction liquid by a centrifuge, and wash the solid phase with water to obtain a calcium succinate solid.

[0031] 4. Calcium succinate is added to the reaction kettle to react with hydrochloric acid at 60°C to generate succinic acid and calcium chloride.

[0032] 5. After the reaction is finished, the temperature of the reaction solution is reduced to 25°C, and the reaction cooling solution is separated with a centrifuge to obtain succinic acid crystals and calcium chloride solu...

Embodiment 2

[0034] The production method of succinic acid comprises the steps:

[0035] 1. earlier with 2 cubic meters of succinic acid concentration is 6% succinic acid fermented liquid 50 ℃ with molecular weight cut-off is 50KD organic membrane filtration, obtains 2.2 cubic meters of concentration and is 5.4% supernatant.

[0036] 2. The succinate solution with a concentration of 5.5% reacted with the calcium chloride by-produced in Example 1 at 60° C. to generate calcium succinate precipitate.

[0037] 3. Separate the reaction liquid by a centrifuge, and wash the solid phase with water to obtain a calcium succinate solid.

[0038] 4. Calcium succinate is added into the reactor to react with hydrochloric acid at 80°C to generate succinic acid and calcium chloride.

[0039] 6. After the reaction is finished, the temperature of the reaction solution is reduced to 20° C., and the reaction cooling solution is separated with a centrifuge to obtain succinic acid crystals and calcium chloride...

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PUM

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Abstract

The invention relates to a method for extracting succinic acid from fermentation liquor, comprising the following steps: 1) degerming and decontaminating succinic acid fermentation liquor to obtain succinate solution; 2) allowing the succinate solution to react with calcium chloride to generate calcium succinate precipitate; 3) carrying out solid-liquid separation on reaction liquid to obtain a calcium succinate solid; 4) allowing the calcium succinate solid to react with hydrochloric acid, and separating out a succinic acid solid at a reduced temperature; and 5) carrying out solid-liquid separation on the reaction liquid to obtain the succinic acid. The method has high yield, good product quality, small original auxiliary material consumption, low energy consumption and applicability to large-scale production.

Description

technical field [0001] The invention relates to the field of food chemical industry, in particular to a method for extracting and separating succinic acid in fermentation broth by adopting a calcium salt precipitation method. Background technique [0002] Succinic acid, also known as succinic acid, is a dibasic organic acid, which is an important C 4 Platform compounds, which can be used as intermediates in the synthesis of complex organic compounds, are widely used in pharmaceuticals, food processing, synthetic plastics, rubber, protective coatings, dyes and other industries. [0003] In the current patents for the preparation of succinic acid by microbial fermentation, the method of separating and extracting succinic acid from the fermentation broth is generally as follows: the fermentation broth is pretreated to remove impurities such as bacteria, and then extracted by ion exchange, electrodialysis or solvent extraction. , and then concentrated and crystallized to obtain...

Claims

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Application Information

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IPC IPC(8): C07C55/10C07C51/02
Inventor 李荣杰尚海涛潘声龙吴鹏举
Owner ANHUI BBCA FERMENTATION TECH ENG RES
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