The invention discloses a two-hole perforating device for a food packaging box side wall paper board. The two-hole perforating device comprises a pedestal, supporting plates, a top plate, a lifting plate, mounting blocks, a first adjusting shaft, first threaded parts, first swivel nuts, connecting pieces, perforating rods, a platform plate, a driven bevel gear, a driving bevel gear and a first motor. Sliding chutes are formed in the lower end of the lifting plate and are further located over the first threaded parts. Sliding blocks are installed on the outer walls of the upper ends of the first swivel nuts, and the top ends of the sliding blocks are arranged in the sliding chutes in a sliding mode. By means of the two-hole perforating device for the food packaging box side wall paper board, the distance between the two perforating rods can be adjusted through the first adjusting shaft, the distance between two holes perforated in the paper board can be adjusted conveniently, and perforating can be conducted as required; movement of the paper board in the perforating mode can be avoided through pressing blocks, and the phenomenon that the paper board is carried away by the perforating rods can also be avoided; and meanwhile, due to arrangement of a half bevel gear, ascending and descending of the lifting plate can be adjusted in a circulation mode without changing the rotating direction of a second motor, and the service life of the second motor is prolonged.