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Ceramide production accelerant

A technology of ceramides and accelerators, applied in skin care preparations, cosmetics, plant raw materials, etc., can solve unknown problems

Active Publication Date: 2010-02-24
ZHONGSHAN HOSPITAL FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, it is completely unknown that such a plant has a ceramide production-promoting effect and a moisturizing effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0032] Production Example 1 Production of Motherwort Extract

[0033] 5 times the amount of petroleum ether was added to 100 g of motherwort, stirred and extracted at 50°C for 1 hour, filtered to obtain a petroleum ether extract, and after the petroleum ether extract was evaporated, about 0.5 g of a petroleum ether extract of the motherwort was obtained.

manufacture example 2

[0034] Production example 2 Production of yam extract

[0035] Substituting 100 g of Motherwort of Production Example 1 with 100 g of yam, extraction was performed in the same way to obtain a petroleum ether extract of yam, and after the petroleum ether extract was evaporated, about 0.3 g of petroleum ether extract of yam was obtained.

Embodiment 1

[0036] Example 1 Ceramide production promotion test

[0037]

[0038] Manufacturing example

[0039]

[0040] Normal human epidermal keratinocytes (NHEK(F)) were cultured in EpiLife-KG2 (KURABO company) 6-well plates, and cultured until they became confluent. After that, it was changed to EpiLife-KG2 (no growth factor added), and the test solution and control solution were added separately. After culturing for 3 days, cells were recovered from each well.

[0041]

[0042] The lipid was extracted from the recovered cells by the Bligh and Dyer method. After drying the extract with nitrogen, the portion redissolved in the chloroform / methanol mixture was prepared as a lipid sample. In addition, the protein quality is quantified by the BCA method.

[0043]

[0044] The extracted lipids were analyzed by thin layer chromatography (TLC). Expand twice in the horizontal direction with chloroform:methanol:acetic acid=190:9:1. Spray with copper sulfate coloring solution, bake on a hot pl...

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PUM

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Abstract

The invention provides a cosmetic or pharmaceutical product capable of recovering and maintaining the shielding function and the moisture-preserving function of the skin, in particular to a ceramide production accelerant or humectant using plants or extractives thereof, such as motherwort and yam as active components.

Description

Technical field [0001] The present invention relates to ceramide production promoters and moisturizers that can increase ceramides and restore the barrier function and moisturizing function of the skin. Background technique [0002] Ceramide, one of the sphingolipids, is a trace amount of lipid in the entire organism, but accounts for more than half of the lipids in the stratum corneum, the outermost layer of the skin, and plays an important role in the skin's moisturizing and barrier mechanisms. . This ceramide is secreted by epidermal cells and then functions by building a lamella structure between cells in the stratum corneum. [0003] However, there are many reports that in skin diseases such as dry skin, rough skin, atopic dermatitis, senile xerosis, and psoriasis, the healthy metabolism of ceramide is hindered, resulting in keratin The amount of ceramide in the skin layer is reduced, causing the skin's moisturizing function and barrier function to decline. [0004] ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K8/97A61P17/00A61Q19/00
Inventor 秦万章杨春欣孔凡旗野尻浩伊藤正太郎
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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