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Extraction method of natural vitamin E

An extraction method and vitamin technology, applied in the production of bulk chemicals, organic chemistry, etc., can solve the problems of low purification efficiency and high content, and achieve high product purity, facilitate large-scale industrial production, and good product quality Effect

Active Publication Date: 2012-10-03
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned articles and patents are all researches on their respective methods, and they are limited to their respective deficiencies. Especially in the preparation of high-purity natural vitamin E, few technologies can achieve it, even column chromatography technology cannot achieve it. High content (above 95%), and the purification efficiency is not high

Method used

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  • Extraction method of natural vitamin E

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 50g of raw material of crude product natural vitamin E (40%) commercially available in the raw material tank T, and input it in the system at a constant speed through the high-pressure pump P2. The carbon dioxide released from the cylinder Q becomes a liquid through the condenser H1, then rises to a predetermined pressure of 7MPa through the high-pressure pump P1, and is heated to a predetermined temperature of 31°C through the heat exchanger H2. After being miscible with the raw materials input by the high-pressure pump P2, it enters the high-pressure column chromatography Separation kettles E1 and E2 are used for separation of effective components. E1 and E2 are column chromatographic separators connected in parallel and equipped with the same adsorption filler alumina, which can be switched for use. The supercritical carbon dioxide fluids that flow out from E1 and E2 and are dissolved with different components pass through the pressure reducing valves 4 and 5 resp...

Embodiment 2

[0020]Put 50g of raw material of crude product natural vitamin E (40%) commercially available in the raw material tank T, and input it in the system at a constant speed through the high-pressure pump P2. The carbon dioxide released from the gas cylinder Q becomes liquid through the condenser H1, then rises to the predetermined pressure of 10MPa through the high-pressure pump P1, and is heated to the predetermined temperature of 55°C through the heat exchanger H2. After being miscible with the raw materials input by the high-pressure pump P2, it enters the high-pressure column chromatography Separation kettles E1 and E2 are used for separation of effective components. E1 and E2 are column chromatography separators connected in parallel and equipped with the same adsorption filler silica gel, which can be switched for use. The supercritical carbon dioxide fluids that flow out from E1 and E2 and are dissolved with different components pass through the pressure reducing valves 4 an...

Embodiment 3

[0022] Put 50g of raw material of crude product natural vitamin E (40%) commercially available in the raw material tank T, and input it in the system at a constant speed through the high-pressure pump P2. The carbon dioxide released from the gas cylinder Q becomes a liquid through the condenser H1, then rises to a predetermined pressure of 20MPa through the high-pressure pump P1, and is heated to a predetermined temperature of 40°C through the heat exchanger H2. After being miscible with the raw materials input by the high-pressure pump P2, it enters the high-pressure column chromatography Separation kettles E1 and E2 are used for separation of effective components. E1 and E2 are column chromatography separators connected in parallel, equipped with the same adsorption filler activated carbon, and can be switched for use. The supercritical carbon dioxide fluids that flow out from E1 and E2 and are dissolved with different components pass through the pressure reducing valves 4 an...

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Abstract

The invention discloses an extraction method of a natural vitamin E, which combines supercritical carbon dioxide extraction and column chromatography separation to extract the natural vitamin E, wherein the pressure of the column chromatography separation is 7 MPa-45 Mpa, the temperature of the column chromatography separation is 31 DEG C-80 DEG C, and absorption fillers used for the column chromatography separation are active carbon and silica gel or aluminium oxide. The extraction method integrates a supercritical carbon dioxide extraction technique and a column chromatography separation technique, combines the respective advantages of the supercritical carbon dioxide extraction technique and the column chromatography separation technique, mutually makes up the respective shortages of the techniques; and the extraction method not only makes up the shortage of the low purity of a product obtained by the purification of the supercritical carbon dioxide extraction technique and but also makes up the shortages of the low yield and efficiency and the like of the column chromatography separation technique and also uses the advantages of the high efficiency and the easy continuous production realization of the supercritical carbon dioxide extraction technique and the high purity of the natural vitamin E obtained by the column chromatography separation technique.

Description

technical field [0001] The invention relates to vitamin E extraction technology, in particular to a vitamin E extraction method. Background technique [0002] Vitamin E (VE), also known as tocopherol, is one of the essential vitamins for the human body. It includes α, β, γ, δ-type tocopherol and corresponding tocotrienol (tocotrienol) and other 8 substances, which have the functions of scavenging free radicals, anti-cancer, anti-cardiovascular disease, improving immunity and anti-aging. There are two types of sources of vitamin E: chemical synthesis and natural products. Natural vitamin E is a dextrorotary form with physiological activity, that is, d-form; while synthetic products are racemic, that is, a mixture of d-form and l-form, so the biological activity of natural vitamin E is more than twice that of synthetic products. Absorption is also higher than synthetic products and has better food safety. There are also differences in the biological activity and functionali...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/72
CPCY02P20/54
Inventor 姚煜东纪红兵
Owner SUN YAT SEN UNIV