Preparation method and application of chitosan copolymer carrier micelle modified by cholesterol formyl chloride

A technology of cholesterol formyl chloride and chitosan copolymer, which is applied in the medical field and can solve problems such as unseen

Inactive Publication Date: 2010-03-03
ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But do not see the open report of the method for the chitosan copolymer drug-loaded micelle of relevant preparation cholesterol formyl chloride modification so far

Method used

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  • Preparation method and application of chitosan copolymer carrier micelle modified by cholesterol formyl chloride
  • Preparation method and application of chitosan copolymer carrier micelle modified by cholesterol formyl chloride

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Embodiment Construction

[0009] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0010] The chitosan copolymer modified by cholesterol formyl chloride among the present invention, its structural formula is as follows:

[0011]

[0012] Wherein, m and n are degrees of polymerization, m+n≤20, the molecular weight of chitosan is 3-50 kDa, the degree of deacetylation is 70-100%, and some amino groups on the chitosan chain are replaced by cholesterol formyl chloride;

[0013] The method for the preparation of cholesterol formyl chloride modified chitosan of the present invention is realized by the following steps:

[0014] 1. Purification of chitosan: take crude chitosan with a molecular weight of 3-50kDa, add 0.1M (M is molar concentration) glacial acetic acid solution (usually solid-liquid mixture, solid-liquid mixture) 65-85 times the weight of chitosan It is measured by weight g, and liquid is measured by volume ml. Th...

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Abstract

The invention relates to a preparation method and an application of chitosan copolymer carrier micelle modified by cholesterol formyl chloride, which can effectively solve the preparation problem of chitosan copolymer carrier micelle modified by cholesterol formyl chloride. The technical scheme comprises the steps of: 1. purifying chitosan; 2. preparing the chitosan copolymer modified by cholesterol formyl chloride; 3. separating and purifying the chitosan copolymer modified by cholesterol formyl chloride; and 4 preparing the chitosan copolymer carrier micelle modified by cholesterol formyl chloride. The method has the characteristic of preparing a colloid solution with stable thermodynamics by self-assembling in a water medium, has simple preparation process and good effect and is an innovation in the medical field.

Description

1. Technical field [0001] The invention relates to the medical field, in particular to a preparation method and application of chitosan copolymer drug-loaded micelles modified by cholesterol formyl chloride. 2. Background technology [0002] Chitosan is a biopolymer obtained by deacetylation of chitin. It is the main derivative of chitin. Chitin and chitosan are nitrogen-containing polysaccharides, and they are also the only natural bases containing free amino groups. Antibacterial polysaccharides have various physiological functions such as antibacterial, anti-cancer, lipid-lowering, and immune-enhancing, and are non-toxic, non-irritating, non-immunogenic, non-pyrogenic, non-hemolytic, non-mutagenic, and naturally degradable. Good tissue compatibility and other characteristics have great medical application value. In the past 20 years, with the discovery of the activity of various derivatives of chitosan, the research on this kind of products is very active all over the wo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36C08B37/08A61K35/00
Inventor 赵永星赵阳张振中张雪晓孙倩
Owner ZHENGZHOU UNIV
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