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Compound anesthetic for dogs

An anesthetic and compound technology, which is applied in the field of compound anesthetics for dogs, can solve problems such as difficulty in controlling the depth and duration of anesthesia, difficulty in applying anesthesia, and great influence on the respiratory and circulatory system, achieving the effect of good controllability of anesthesia

Inactive Publication Date: 2011-06-01
NANJING AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Technical Problem The purpose of the present invention is to rationally combine the three drugs of ketamine, midazolam and xylazine to achieve better anesthesia effect and the lowest side effects, while overcoming the induction time, maintenance time and recovery time in the prior art. It takes a long time and has a great impact on the respiratory and circulatory system; and it is administered by intramuscular injection, it is difficult to control the depth and maintenance time of anesthesia, and it is difficult to apply to anesthesia for complex or long-term operations.

Method used

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  • Compound anesthetic for dogs
  • Compound anesthetic for dogs
  • Compound anesthetic for dogs

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Effect test

Embodiment Construction

[0020] (1) Experimental animals: 170 ICR mice, 4 weeks old, half male and half female, weighing 20±2g, were purchased from the Experimental Animal Center of Nanjing Medical University, and the experiment was started after two weeks of feeding under the same conditions; dogs, 9 ( 5) females, 4 males, 24.39±2.68kg, 18-24 months old, purchased from a kennel.

[0021] (2) Prescription test

[0022] 1. Orthogonal test

[0023] On the basis of the previous research in our laboratory, according to the design principle of three-factor three-level orthogonal experiment, the ICR mice were divided into L9(3 4 ) were arranged into 9 test groups with 14 rats in each group. Taking the dosage of each component in the pre-determined prescription as the middle dose, it is divided into three levels (see Table 1). The volume of each group of medicinal solution was adjusted to 10mL, and injected intraperitoneally at 0.01mL / g body weight, the righting reflex of each group was observed, and the ...

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Abstract

The invention relates to a compound anesthetic for dogs, which belongs to the technical field of veterinary drug preparation and is suitable for stopping and anesthetizing dogs. The preparation method of the compound anesthetic for dogs comprises the following steps: sequentially dissolving 0.3g of citric acid, 1g of sodium citrate, 0.09g of methyl p-hydroxybenzoate, 0.01g of propyl p-hydroxybenzoate, 8g of ketamine hydrochloride, 0.2g of midazolam hydrochloride and 0.9g of xylazine hydrochloride into water for injection for preparing each 100ml of solution, filtering the solution, filling and sealing the solution into an ampoule, and sterilizing to obtain the compound anesthetic. The compound anesthetic for dogs preferably selects the formula through an orthogonal test, integrates the advantages of each drug, greatly reduces the side effect when each drug is used singly, and has stable anesthetizing and waking processes. Compared with the prior art, the induction time, the maintaining time, the stage of surgical anesthesia and the waking time are respectively shortened by 81.67%, 81.45%, 73.33% and 48.28%, and the anesthetizing controllability is greatly improved; the influence on each physiological parameter is little; and moreover, the compound anesthetic is taken intravenously, thus the dose can be supplemented for many times according to the operation requirements, and the compound anesthetic can be used for complicated operations and long-lasting operations.

Description

1. Technical field [0001] The invention relates to a compound anesthetic for dogs, belonging to the technical field of veterinary drug preparation. It is suitable for immobilization and anesthesia of dogs. 2. Background technology [0002] The purpose of veterinary clinical anesthesia is to ensure animal safety, meet surgical needs, relieve pain and treat injuries. With the advancement of domestic veterinary clinical anesthesia technology, traditional single anesthesia can no longer meet the needs of clinical anesthesia. Single anesthesia has been replaced by compound anesthesia, and the related research and application of compound anesthesia preparations has become a new trend in the development of modern veterinary anesthesia. [0003] At present, domestic drugs for clinical anesthesia of canine diseases mainly include compound anesthesia preparations such as Sumianxin and Quanmianbao. Sumianxin and Quanmianbao have good sedative, analgesic and muscle relaxing effects, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5517A61K31/54A61K31/135A61P23/00
Inventor 侯加法李培德孙丽盈贺卫华翟晓虎邓益锋周振雷
Owner NANJING AGRICULTURAL UNIVERSITY
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