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Preparation method of fucosan

A fucoidan and concentration technology, applied in the field of fucoidan preparation, can solve the problems of not considering the removal of heavy metals, affecting product quality, and high heavy metal content

Inactive Publication Date: 2010-03-03
JIMEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the past, in the process of preparing fucoidan, the problem of removing the combined heavy metals was not considered, resulting in a high content of heavy metals in the preparation of fucoidan, which affected the quality of the product

Method used

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  • Preparation method of fucosan

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Effect test

Embodiment 1

[0014] The present invention is a kind of preparation method of fucoidan, comprises the following steps:

[0015] (1) Get 100kg of dried kelp, remove sand and sundries, dry, pulverize, and sieve 80 meshes to make kelp dry powder.

[0016] (2) Take 50Kg of the above-mentioned kelp dry powder, add 1000Kg of deionized water, and stir evenly. After incubating at 80° C. for 3 hours, centrifuge in a tubular continuous centrifuge (10,000 rpm for 10 minutes) to obtain about 300 kg of supernatant.

[0017] (3) Concentrated hydrochloric acid (HCl) was adjusted to a concentration of 4 mol / L, and added to the above-mentioned supernatant in proportion to make the concentration of HCl reach 0.1 mol / L. After standing for 15 minutes, use a tubular continuous centrifuge to centrifuge, and the precipitate is mainly alginic acid impurities. Get supernatant about 250Kg.

[0018] (4) Solid sodium hydroxide (NaOH) is formulated into a 6N concentration solution, which is used to neutralize the su...

Embodiment 2

[0027] The present invention is a kind of preparation method of fucoidan, comprises the following steps:

[0028] (1) Get 100kg of dried kelp, remove sand and sundries, dry, pulverize, and sieve 80 meshes to make kelp dry powder.

[0029] (2) Take 50Kg of the above-mentioned kelp dry powder, add 900Kg of deionized water, and stir evenly. After incubating at 75° C. for 3 hours, centrifuge in a tubular continuous centrifuge (600 rpm for 12 minutes) to obtain about 300 kg of supernatant.

[0030] (3) Concentrated hydrochloric acid (HCl) was adjusted to a concentration of 4 mol / L, and added to the above-mentioned supernatant in proportion to make the concentration of HCl reach 0.1 mol / L. After standing for 18 minutes, it was centrifuged in a tubular continuous centrifuge, and the precipitate was mainly alginic acid impurities. Get supernatant about 250Kg.

[0031] (4) Solid sodium hydroxide (NaOH) is formulated into a 6N concentration solution, which is used to neutralize the s...

Embodiment 3

[0036] The present invention is a kind of preparation method of fucoidan, comprises the following steps:

[0037] (1) Get 100kg of dried kelp, remove sand and sundries, dry, pulverize, and sieve 80 meshes to make kelp dry powder.

[0038] (2) Take 50Kg of the above-mentioned kelp dry powder, add 950Kg of deionized water, and stir evenly. After incubating at 77° C. for 3.5 hours, centrifuge in a tubular continuous centrifuge (800 rpm for 15 minutes) to obtain about 300 kg of supernatant.

[0039] (3) Concentrated hydrochloric acid (HCl) was adjusted to a concentration of 4 mol / L, and added to the above-mentioned supernatant in proportion to make the concentration of HCl reach 0.1 mol / L. After standing for 20 minutes, use a tubular continuous centrifuge to centrifuge, and the precipitate is mainly alginic acid impurities. Get supernatant about 250Kg.

[0040] (4) Solid sodium hydroxide (NaOH) is formulated into a 6N concentration solution, which is used to neutralize the supe...

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Abstract

The invention discloses a preparation method of fucosan. On the basis of the traditional preparation technology of the fucosan, HCl is adopted to adjust the pH value of solution, and metal chelating agent EDTA is added, so as to lead heavy metal ions originally chelated on the fucosan sulfate groups to shed off and form chelates with the EDTA. By adopting an ultrafiltration technology, the EDTA-heavy metal chelates are separated from the fucosan, and concentrated, and the fucosan after the removal of heavy metal elements can be prepared through freeze-drying. The preparation method has the advantages of simple operation, mild conditions, high shedding rate of heavy metal ions, low cost and the like, and is suitable for large-scale operations.

Description

technical field [0001] The present invention relates to a method for preparing fucoidan from seaweed and removing heavy metal ions, in particular to the technical method of combining pH adjustment with metal ion chelating agent EDTA to remove heavy metal elements As, Preparation method of Ag, Cd, Pb fucoidan. Background technique [0002] Fucoidan is an acidic sulfate polysaccharide present in the cell wall of brown algae (such as kelp), and its molecular structure contains sulfate ( ＝ SO 4 ) and uronic acid (COOH) and other structural components, so that the polysaccharide has the characteristics of a polyanion system, which can bind heavy metal ions in the ocean (such as As +2 、Ag +2 、Cd +2 , Pb +3 ). Heavy metals are extremely harmful to the human body. Although these heavy metals exist in a complex form in fucoidan, once the polysaccharide enters the human body, due to the acidic medium conditions of the intestinal tract, these heavy metal elements may be dissociat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 吴永沛刘翼翔
Owner JIMEI UNIV
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