Method for preparing polymer micro balls with uniform grain diameter and controllable size

A polymer, homogeneous technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of complex experimental equipment and high cost, and achieve the effects of simple equipment, smooth appearance and low investment cost

Inactive Publication Date: 2010-04-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these two methods can produce polymer microspheres with relatively uniform particle size, the experimental equipment is complicated and the cost is high.

Method used

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  • Method for preparing polymer micro balls with uniform grain diameter and controllable size
  • Method for preparing polymer micro balls with uniform grain diameter and controllable size
  • Method for preparing polymer micro balls with uniform grain diameter and controllable size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Preparation of polylactic acid microparticles

[0019] A certain mass of polylactic acid (molecular weight: 22,000) was weighed and dissolved in methylene chloride to obtain a dispersed phase with a concentration of 0.5% g / ml. A certain mass of polyvinyl alcohol-124 was weighed and dissolved in water to obtain a continuous phase with a concentration of 0.1% g / ml. Measure 250ml of the continuous phase into the reactor, and adjust the temperature of the continuous phase to 20°C with a constant temperature device. Turn on the stirring device and adjust the rotating speed to 100 rpm. Turn on the constant flow device, so that the injection rate of the dispersed phase is 0.5ml / min, the injection volume of the dispersed phase is 10ml, and the inner diameter of the orifice is 10μm. After the injection of the dispersed phase is completed, the stirring is continued for 0.5 hour, so that the droplets of the dispersed phase are solidified into polylactic acid micros...

Embodiment 2

[0020] Embodiment 2: Preparation of polylactic acid microparticles

[0021] A certain mass of polylactic acid (molecular weight 8000) was weighed and dissolved in ethyl acetate to obtain a dispersed phase with a concentration of 10.0% g / ml. A certain mass of polyvinyl alcohol-124 was weighed and dissolved in water to obtain a continuous phase with a concentration of 5.0% g / ml. Measure 1000ml of the continuous phase into the reactor, and adjust the temperature of the continuous phase to 50°C with a constant temperature device. Turn on the stirring device and adjust the rotating speed to 1000rpm. Turn on the constant flow device so that the injection rate of the dispersed phase is 10.0ml / min, the injection volume of the dispersed phase is 10ml, and the inner diameter of the orifice is 300μm. After the injection of the dispersed phase is completed, the stirring is continued for 4.0 hours, so that the droplets of the dispersed phase are solidified into polylactic acid microspher...

Embodiment 3

[0022] Embodiment 3: Preparation of polylactic acid microparticles

[0023] A certain mass of polylactic acid (molecular weight: 22,000) was weighed and dissolved in methylene chloride to obtain a dispersed phase with a concentration of 4.0% g / ml. A certain mass of polyvinyl alcohol-124 was weighed and dissolved in water to obtain a continuous phase with a concentration of 1.0% g / ml. Measure 600ml of the continuous phase into the reactor, and adjust the temperature of the continuous phase to 35°C with a constant temperature device. Turn on the stirring device and adjust the rotating speed to 300rpm. Turn on the constant flow device so that the injection rate of the dispersed phase is 1.0ml / min, the injection volume of the dispersed phase is 10ml, and the inner diameter of the orifice is 200μm. After the injection of the dispersed phase is completed, the stirring is continued for 1 hour, so that the droplets of the dispersed phase are solidified into polylactic acid microsphe...

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Abstract

The invention discloses a method for preparing polymer micro balls with uniform grain diameter and controllable size, which comprises the following steps: a disperse phase (organic solution of polymers) is introduced into a continuous phase (water solution containing surfactant) through an orifice device; under the scouring action of the continuous phase, the disperse phase forms tiny liquid drops with uniform grain diameter; and after being solidified in the continuous phase without a solvent, the liquid drops form the polymer micro balls with uniform grain diameter. The invention is characterized in that the grain diameter of the polymer micro balls can be changed by adjusting the operation parameters to prepare the polymer micro balls with uniform grain diameter; and the average grain diameter of the polymer micro balls with uniform grain diameter can be adjusted within the range of 10-1000 micrometers, and the dispersion coefficient is smaller than 20%. The prepared polymer micro balls have the advantages of uniform grain diameter, low dispersion coefficient, smooth surface and no adhesion; and the method has the advantages of strong adjustability, simple equipment and stable operation.

Description

technical field [0001] The invention relates to a method for preparing polymer microspheres with uniform particle size and controllable size. The prepared polymer microspheres are mainly used in the pharmaceutical sustained-release preparation industry. Background technique [0002] In recent years, polymer microspheres have been widely used as sustained-release drug carriers. Generally speaking, the particle size distribution of polymer microspheres used as sustained-release drug carriers is required to be within a relatively narrow range. For example, the sustained-release drug particles used to embolize the blood vessels of cancerous tissues generally require a particle size of 20-40 microns (Chinese Journal of Hospital Pharmacy, 2004, 24: 74-75); the drug particles used for pulmonary aerosol administration, It is 1-5 microns (Journal of Supercritical Fluids, 2003, 26: 243-252). [0003] At present, the commonly used methods for preparing polymer microspheres mainly in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14C08L67/04
Inventor 关怡新余金鹏姚善泾朱自强
Owner ZHEJIANG UNIV
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