Sustained-release pill of total alkaloids from strychnos and method for preparing same

A technology of total alkaloids and sustained-release dripping pills, which is applied in the fields of pill delivery, drug combination, and pharmaceutical formulations. It can solve the problems of physical hazards for workers, environmental pollution, and large dust pollution. The effect of low production cost

Inactive Publication Date: 2010-05-05
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Conventional dosage forms such as tablets and capsules will generate large dust pollution during the preparation process

Method used

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  • Sustained-release pill of total alkaloids from strychnos and method for preparing same
  • Sustained-release pill of total alkaloids from strychnos and method for preparing same
  • Sustained-release pill of total alkaloids from strychnos and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 0.168g (1% wt) total alkaloid powder of Nuxychnium chinensis, add 90%wt ethanol solution with pH 3.0, stir while adding, so that the total alkaloids of Nuxychnium chinensis just dissolve. The hydrophilic matrix is ​​mixed with 14.78g (88%wt) and 1.848g (11%wt) of hydrophobic matrix stearic acid in the ratio of PEG4000:PEG6000=4:5, heated at 90°C, and melted. Add the ethanol solution of the total alkaloids of Nuxychnium chinensis, heat in an oil bath at 105°C, stir for 1 hour, and volatilize to remove ethanol and water. Add the medicine and matrix in the molten state to the feed liquid bin of the dripping pill device, control the temperature of the feed liquid bin at 90°C, keep it for 30-60 minutes, adjust the distance between the dripper and the cooling liquid to 3cm, and the dripping speed to 20 drops / Minutes, the length of the cooling column is 100cm, and the cooling liquid is liquid paraffin. The formed drop pills are taken out from the collection bottle at th...

Embodiment 2

[0032] Take 1.122g (5% wt) total alkaloid powder of Nuxychnium, add 90%wt ethanol solution with pH 3.0, stir while adding, so that the total alkaloids of Nuxychnium just dissolve. 19.074g (85%wt) of hydrophilic matrix (ratio of substance amount PEG4000:PEG6000=0.5:1) and 2.244g (10%wt) of hydrophobic matrix stearic acid were mixed, heated at 90°C, and melted. Add the ethanol solution of the total alkaloids of Strychnium chinensis, heat in an oil bath at 105°C, stir for 2 hours, and volatilize to remove ethanol and water. Add the medicine and matrix in the molten state to the feed liquid bin of the dripping pill device, control the temperature of the feed liquid bin to 85°C, and maintain it for 30 minutes, adjust the distance between the dripper and the cooling liquid to 4cm, and the dripping speed to 20 drops / min. The cooling column is 120cm long. The formed drop pills are taken out from the collection bottle at the lower part of the drop pill device, the liquid paraffin on t...

Embodiment 3

[0034] Take 1.601g (8% wt) total alkaloid powder of Nuxychnium, add 90%wt ethanol solution with pH 3.0, stir while adding, so that the total alkaloids of Nuxychnium just dissolve. 16.010g (80%wt) of the hydrophilic matrix (the ratio of substances is PEG4000:PEG6000=2:1) ​​and 2.402g (12%wt) of the hydrophobic matrix stearic acid were mixed, heated at 90°C, and melted. Add the ethanol solution of the total alkaloids of Nuxychnium chinensis, heat in an oil bath at 105°C, stir for 1.5 hours, and remove the ethanol and water by volatilization. Add the medicine and matrix in the molten state to the feed liquid bin of the dropping pill device, control the temperature of the dropping pill part at 95°C, and maintain it for 30 minutes. The column length is 100 cm. The prepared dropping pills are taken out from the collection bottle at the lower part of the dropping pill device, the liquid paraffin on the surface is sucked off with absorbent paper, and dried to obtain the total alkaloi...

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Abstract

The invention discloses a sustained-release pill of total alkaloids from strychnos and a method for preparing the same. The sustained-release pill of total alkaloids from strychnos has high bioavailability, controllable release and long pain-relieving time, is taken for fewer times, is safe and reliable and can not cause pollution when being produced. The strychnine and strychnine is used as the active component of the sustained-release pill of total alkaloids from strychnos and is mixed with hydrophilic matrix material and hydrophobic matrix material which are used as matrix to prepare the sustained-release pill of total alkaloids from strychnos. The sustained-release pill of total alkaloids from strychnos comprises the following components by weight percent: 1-8 percent of the strychnine, 80-88 percent of hydrophilic matrix material and 10-12 percent of hydrophobic matrix material, wherein the hydrophilic matrix material is the mixture of polyethylene glycol 4000 and polyethylene glycol 6000, and the hydrophobic matrix material is stearic acid.

Description

technical field [0001] The invention belongs to the technical field of sustained-release pharmacy, and in particular relates to a sustained-release medicine of Nuxebra nuxeur for treating pain caused by rheumatoid or arthritis-like diseases. Background technique [0002] Obstinate numbness belongs to the category of "bi syndrome" in traditional Chinese medicine, including rheumatoid arthritis and other diseases in modern medicine. Rheumatoid arthritis is a chronic, systemic immune disease mainly characterized by joint disease. Mostly due to the deficiency of righteousness and the invasion of wind-cold-damp evil, complex pathological changes of deficiency of righteousness and excess of evil are formed. The clinical manifestations are joint pain, especially the lesions of the small joints of the distal extremities, and even joint stiffness and deformity, dysfunction or loss of function, and bone and skeletal muscle atrophy. Because of its long course of disease, lingering co...

Claims

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Application Information

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IPC IPC(8): A61K36/56A61K9/20A61K47/34A61P29/00A61P19/02A61P19/04A61K131/00A61K47/10
Inventor 颜辉边旭云徐大宝桂仲争江明珠
Owner JIANGSU UNIV OF SCI & TECH
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