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Biologic degradable magnesium alloy medicine supporter for reconstructing blood circulation and preparation method

A technology for degrading polymers and magnesium alloys, applied in stents, pharmaceutical devices, medical science, etc., can solve the problems of poor targeting, difficulty in promoting angiogenesis, and short half-life, so as to delay the degradation time and benefit Restoration of function, in vivo effect, less inflammatory response

Inactive Publication Date: 2010-05-19
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides improved medical devices made with magnetic materials that have excellent properties such as strength, durability, flexibility, etc., which make them suitable for use inside living organisms like humans without causing complications during their implanted state. These technical benefits include reducing patient risk by avoiding permanent damage caused by foreign objects introduced into the human body through surgery while still providing effective treatment options on cardiac disease patients who require temporary heart blockage.

Problems solved by technology

Technologies related to this patented technical problem addressed in this patent include developing a bioreactor called MSC/CIMBP which helps create temporary catheter systems through minimizing damage from foreign objects during procedures while still providing effective therapeutic benefits over longer periods without causing complications like blockages associated with traditional techniques. Additionally, controlling the amount released within specific areas allows for controlled delivery of drugs, reducing adverse events including bleeding.

Method used

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  • Biologic degradable magnesium alloy medicine supporter for reconstructing blood circulation and preparation method
  • Biologic degradable magnesium alloy medicine supporter for reconstructing blood circulation and preparation method
  • Biologic degradable magnesium alloy medicine supporter for reconstructing blood circulation and preparation method

Examples

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Embodiment 1

[0024] A biodegradable magnesium alloy drug stent for revascularization, including a hollow tube 1, the hollow tube is made of magnesium-aluminum alloy with a magnesium mass percentage of 99.9%, the inner diameter of the tube is 2.4 mm, and the wall thickness is 0.3 mm. The length is 0.5 cm, and the wall of the hollow tube is provided with 8 small holes 2 with a diameter of 0.2 mm through the wall. For ester layer 3, the ratio of basic fibroblast growth factor, heparin and polycaprolactone is 30ug:20mg:0.2g.

[0025] Myocardial revascularization animal experiment The experimental pig was anesthetized by injection of pentobarbital sodium to establish a myocardial ischemia model. The thorax and pericardium were opened along the median of the sternum to expose the heart. After penetrating the heart wall, the blood is ejected from the heart cavity, and the biodegradable magnesium alloy drug stent for revascularization prepared by the present invention is quickly placed in the myoc...

Embodiment 2

[0027] A method for preparing a biodegradable magnesium alloy drug stent for revascularization, comprising the following steps: using magnesium as a material to prepare a hollow tubular stent with an inner diameter of 2.4mm, a wall thickness of 0.3mm, and a length of 1cm by mechanical processing, and using electric The mechanical drill drills evenly through small holes around the side wall of the tube, the hole diameter is 1mm, the number of small holes is 4 per week, and there are 16 small holes in 4 rows. Add dichloromethane to polycaprolactone-polylactic acid copolymer (the molar ratio is 60 / 40), make the dichloromethane solution of the polymer that concentration is 10% (g / ml), fully stir, dissolve, take above-mentioned solution 1ml, take the β-type transforming growth factor of 50ug to disperse evenly In the dichloromethane solution of the polymer, add it to the syringe, and under the voltage of 13KV and the flow rate of 10ul / ml, the nanofibers are made by electrospinning e...

Embodiment 3

[0029] A method for preparing a biodegradable magnesium alloy drug stent for revascularization, comprising the following steps: using a magnesium-manganese alloy with a magnesium mass percentage of 90% as a material and preparing it into an inner diameter of 2.4 mm and a wall thickness of 0.3 mm by mechanical processing. mm, a hollow tube with a length of 3 cm, use an electromechanical drill bit with a diameter of 1 mm to evenly punch through small holes on the side wall of the tube, the number of small holes is 50, and dichloromethane is added to the polycaprolactone-polylactic acid copolymer (the molar ratio is 60 / 40), be made into the methylene chloride solution of the polycaprolactone-polylactic acid copolymer that concentration is 15% (g / ml), fully stir, dissolve; By the ratio of 50ug: 40mg, β Type transforming growth factor and heparin were uniformly dispersed in 1ml polycaprolactone-polylactic acid copolymer in dichloromethane solution, and evenly sprayed on the inner an...

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Abstract

The invention discloses a biologic degradable magnesium alloy medicine supporter for reconstructing blood circulation, which comprises a hollow conduit, wherein the material of the hollow conduit is magnesium or magnesium alloy, the hollow conduit is a conduit of which the conduit wall is provided with 0-50 small holes with the diameter of 0.2-1mm, or a conduit with a porous reticular structure, or a conduit with a spiral tubular structure, and biologic degradable polymer layers which contain cell growth factors or/and heparin are arranged on the internal surface and the external surface of the hollow conduit. Because of adopting the magnesium or the magnesium alloy as a raw material, the medicine supporter has better radial support performance, can prohibit the closure of hole canals used for reconstructing the blood circulation, keeps the smooth perfusion of the blood flow of the hole canals and can also promote the direct perfusion of the blood flow to muscles at the side wall by the side holes of the supporter; the medicine supporter has better biologic compatibility and smaller inflammatory reaction of the in-vivo function; the medicine supporter can promote the regeneration of blood vessels and act as the function of resisting blood coagulation; and the medicine supporter can promote the reconstruction of the blood circulation of cardiac muscles with ischemia or lower extremities with ischemia.

Description

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Claims

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Application Information

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Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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