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Controllable biological degradable polyester superfine fibrous film material

A microfiber and biodegradable technology, applied in the direction of medical preparations, coatings, and medical science of non-active ingredients, can solve the problems of undiscovered controllable degradation, achieve adjustable degradation speed, simple preparation process, The effect of shortening the degradation time

Inactive Publication Date: 2007-09-05
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No research reports or invention patents have been found on the addition of biologically active enzymes to PLA and PCL substrates to enable them to degrade under control

Method used

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  • Controllable biological degradable polyester superfine fibrous film material

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Abstract

A controllable biological degradable polyester superfine fiber film consists of PLLA, PLGA or PEG-PLA 95-99.9%, protease K 0.1-5%, PCL or PLCL 90-99% and lipase PS 1-10%. The diameter of fiber is 50nm-600nm and thickness is 10 mu m-100 mu m. It's simple, has short degradable time and adjusting degradable speed.

Description

technical field The invention relates to a controllable biodegradable polyester ultrafine fiber membrane material, which belongs to the technology of tissue repair substitute material and drug controlled release carrier material. Background technique Polylactide (PLA) and polyε-caprolactone (PCL) have good biocompatibility and biodegradability, and can be combined with other inorganic bioactive materials, so they are widely used in bone internal fixation materials, bone replacement materials, tissue engineering scaffold materials and drug controlled release carrier materials, etc. However, due to the slow degradation rate of PLA and PCL, the degradation cycle is generally more than one year and is not easy to be adjusted by the environment, so it cannot meet the actual application requirements of short-term biological alternative materials. The inventor of this patent application has studied the in vitro degradation performance of poly(lactide-co-glycolide) (PLGA) and its ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L67/04C08L71/00A61L27/18A61L31/10A61K47/34
Inventor 袁晓燕李晓然
Owner TIANJIN UNIV
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