Mushroom polysaccharide chitosan nanoparticle and preparation method thereof

Abstract

The invention discloses a mushroom polysaccharide chitosan nanoparticle and a preparation method thereof, and the mushroom polysaccharide chitosan nanoparticle is prepared by the following parts by weight of pharmaceutical raw materials and carrier material: 150-250 parts of chitosan, 30-70 parts of sodium tripolyphosphate and 0.6-1.5 parts of mushroom polysaccharide. The chitosan is adopted as a carrier, a drug-loaded nanoparticle is self-formed through the electrostatic action of anions and cations of the chitosan and the sodium tripolyphosphate, and the mushroom polysaccharide chitosan nanoparticle with high stability, good encapsulation efficiency and high drug loading capacity is successfully prepared by combining the ion gelatinization method with the double emulsion-solvent evaporation method for loading water soluble and macromolecular mushroom polysaccharide. The mushroom polysaccharide chitosan nanoparticle has good anti-tumor effect and immune enhancement effect; compared with mushroom polysaccharide solution, the mushroom polysaccharide chitosan nanoparticle has stronger anti-tumor effect and higher stability. The preparation method has the advantages of simple operation, safety and effectiveness and is in line with the environmental protection requirement and applicable to industrial production.

Description

technical field The invention relates to the field of pharmaceutical nano preparations, in particular to a lentinan chitosan nanoparticle and a preparation method thereof. Background technique Polysaccharides are formed by the condensation and dehydration of multiple monosaccharide molecules. There are various types and complex structures, and they are widely distributed in animals and plants. At present, there are many studies on the physical and chemical properties and biological functions of polysaccharides. In recent years, some researchers have carried out further research and development on the potential functions of polysaccharides from different sources, which has attracted wide attention in the application of polysaccharides in the field of medicine. At present, an important application field of polysaccharides is anti-tumor. Through research, it is found that the anti-tumor effects of polysaccharides are as follows: on the one hand, they exert anti-tumor effects b...

AI Technical Summary

Problems solved by technology

The invention provides a nano-particle of lentinan and chitosan, which is used to make up the blank of the existing nano-preparation of lentinan, which adopts chitosan and sodium tripolyphosphate as carrier materials, and carries the lentinan by ion gelation Successfully prepared nanoparticles with high stability and good encapsulation efficiency, which overcomes the difficulty of preparing nano-preparations due to its water solubility, macromolecules and other properties that are not conducive to encapsulation

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