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Agomelatine-containing medicinal composition

A technology of agomelatine and its composition, which is applied in the field of preparation of agomelatine and its preparation, and can solve the problems of no legal source, inability to use preparations for industrial production, and difficulty in obtaining them

Active Publication Date: 2010-06-16
万全万特制药江苏有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN03802710.0 discloses the and other excipients, It is a new compound made of 15% corn starch and 85% lactose monohydrate through spray drying-coagulation. This excipient needs to be imported, which is expensive and difficult to obtain relevant legal qualifications. There is no legal source and cannot be used in preparations Industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Element

[0014] Mix agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add starch slurry to moisten, make soft material, granulate, dry, granulate, add 50% sodium starch glycolate and magnesium stearate, compressed into tablets.

Embodiment 2

[0016] Element

[0017] Mix agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add starch slurry to moisten, make soft material, granulate, dry, granulate, add 50% sodium starch glycolate and magnesium stearate, compressed into tablets.

Embodiment 3

[0019] Element

[0020] Mix agomelatine, lactose, starch, and 50% sodium starch glycolate in equal amounts, add starch slurry to moisten, make soft material, granulate, dry, granulate, add 50% sodium starch glycolate and magnesium stearate, compressed into tablets.

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PUM

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Abstract

The invention provides an agomelatine-containing medicinal composition, which not only solves the problem of the dissolution of agomelatine in different crystal forms, but also meets the requirements of preparations for prescriptions and processes. The composition has the advantages of simple preparation process, convenience for operation, transport and storage, wide application range and suitability for large-scale production.

Description

technical field [0001] A pharmaceutical composition containing agomelatine, in particular to a preparation of agomelatine and a preparation method thereof. Background technique [0002] Agomelatine is a selective agonist of melatoninergic receptors on the one hand and an antagonist of 5-HT2C receptors on the other. It is active in the treatment of major depression, seasonal depressive disorder, sleep disorders, cardiovascular disease, digestive system disease, insomnia, fatigue due to jet lag, appetite disturbance and obesity. [0003] European patent EP 0447285 discloses the preparation method of agomelatine and its therapeutic effect. [0004] Chinese patent CN03802710.0 discloses the and other excipients, It is a new compound made of 15% corn starch and 85% lactose monohydrate through spray drying-coagulation. This excipient needs to be imported, which is expensive and difficult to obtain relevant legal qualifications. There is no legal source and cannot be used in p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61P25/24A61P25/20A61P9/00A61P1/00A61P3/04
Inventor 刘海丽张晓
Owner 万全万特制药江苏有限公司
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