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Antibacterial gel and preparation method thereof

A technology of gel and gel matrix, which is applied to antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Long-lasting and effective effects

Active Publication Date: 2013-01-23
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many antibacterial varieties on the market, most of which are antibacterial lotions, which have shortcomings such as short administration time and insufficient long-lasting efficacy.

Method used

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  • Antibacterial gel and preparation method thereof
  • Antibacterial gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Polyhexamethylene biguanide hydrochloride 50g borneol 10g propylene glycol 1000g

[0022] Hydroxyethyl cellulose 250g Purified water 9000g

[0023] Preparation method:

[0024] Take the prescribed amount of polyhexamethylene biguanide hydrochloride and add it to 8000g of purified water to dissolve, then add hydroxyethyl cellulose and stir for 30 minutes, and let it stand for 4 hours to fully swell to obtain a gel matrix;

[0025] Get the borneol of prescription quantity and add in the propylene glycol of prescription quantity, stir and make it dissolve, obtain mixed liquor;

[0026] Add the mixed solution into the gel matrix, then add 1000g of purified water, and stir well to obtain the antibacterial gel of the present invention.

Embodiment 2

[0028] Polyhexamethylene biguanide hydrochloride 3g borneol 0.5g propylene glycol 80g

[0029] Hydroxyethyl cellulose 20g Purified water 800g

[0030] Preparation method:

[0031] Take the prescribed amount of polyhexamethylene biguanide hydrochloride and add it to 600g of purified water to dissolve, then add hydroxyethyl cellulose and stir for 20 minutes, and let it stand for 3 hours to fully swell to obtain a gel matrix;

[0032] Get the borneol of prescription quantity and add in the propylene glycol of prescription quantity, stir and make it dissolve, obtain mixed solution;

[0033] Add the mixed solution into the gel matrix, then add 200g of purified water, and stir well to obtain the antibacterial gel of the present invention.

Embodiment 3

[0035] Polyhexamethylene biguanide hydrochloride 7g borneol 1.5g propylene glycol 120g

[0036] Hydroxyethyl cellulose 30g Purified water 1000g

[0037] Preparation method:

[0038] Take the prescribed amount of polyhexamethylene biguanide hydrochloride and add it to 900 g of purified water to dissolve, then add hydroxyethyl cellulose and stir for 60 minutes, and let it stand for 6 hours to fully swell to obtain a gel matrix;

[0039] Get the borneol of prescription quantity and add in the propylene glycol of prescription quantity, stir and make it dissolve, obtain mixed solution;

[0040] Add the mixed solution into the gel matrix, then add 100g of purified water, and stir well to obtain the antibacterial gel of the present invention.

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Abstract

The invention discloses an antibacterial gel with good sterilizing and itch relieving efficacies and a preparation process thereof. The antibacterial gel comprises polyhexamthylene guanidine hydrochloride and borneol. The preparation method comprises the processes of preparing a substrate, proportioning and the like, and finally the antibacterial gel with exact curative effects and low toxic sideeffect is obtained. The antibacterial gel is mainly used for killing pathogens of staphyiococcus aureus, candida albicans, colibacillus and the like which result in gynecological inflammation, and has good social benefit and economic benefit.

Description

technical field [0001] The invention relates to an antibacterial gel and a preparation process thereof. Background technique [0002] Gynecological diseases threaten the health of women in my country, showing a trend of rejuvenation; the incidence of gynecological diseases in women of childbearing age is over 70%; almost 100% of women have suffered from varying degrees of vaginitis in their lives, and more than 5% of them have seriously affected normal work due to illness and life; there are more than 400 million women in my country who are involved in gynecological medicines. Gynecological inflammation is mainly divided into vaginitis, cervicitis and pelvic inflammatory disease. The prevalence of gynecological diseases in married women in my country is 46.10%, 48.85% in rural women, and 41.26% in cities. The high prevalence and high recurrence rate are gynecological diseases. The main characteristics of inflammatory diseases, the market demand for therapeutic drugs in this f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/785A61K31/045A61P15/02A61P31/04
Inventor 陈丽芬
Owner 广西壮族自治区花红药业集团股份公司
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