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Dermis trace intervention anti-wrinkle cosmetic preparation and method

A dermis, trace technology, applied in skin diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as limiting the effect and influence of active ingredients

Inactive Publication Date: 2010-07-28
孙杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Due to the presence of epidermal barriers in healthy skin, water, oil, electrolytes, and protein macromolecules cannot freely enter and exit the stratum corneum of the epidermis, so that conditioning and repairing ingredients such as rhPDGF can only enter a very small part of the dermis through channels such as hair follicles and sweat glands, affecting Limit the action of these active ingredients

Method used

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  • Dermis trace intervention anti-wrinkle cosmetic preparation and method

Examples

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preparation example Construction

[0020] Preparation of freeze-dried powder preparation: the active ingredient, functional ingredient and auxiliary ingredient are prepared into an aqueous solution with low-temperature purified water, and placed in an ice bath for subsequent use. The above aqueous solution was divided into clean vials, the rubber stopper was half-stoppered, and placed in a lyophilizer. Turn on the vacuum freeze-drying agent to lower the temperature of the preparation to -60°C, and the cooling time is delayed for 3-6 hours. Start the vacuum pump to draw the vacuum in the working room to 0.3MPa. Gradually heat up and sublimate, and the sublimation time is 12-24 hours. After the sublimation of the water in the preparation is completed, the working room is filled with nitrogen, the plug is pressed, and the cap is crimped for packaging.

[0021] Manufacture of special lysozyme: Dissolve auxiliary components in PBS solution with pH 5.0-7.4, add glycerol, mix evenly, dispense into vials according to...

Embodiment 1

[0023] Measure rhPDGF 0.01g~0.1g, TGF 0.001g~0.1g, HA 1g~10g, mannitol 10~100g, dextran 10~100g, water-soluble collagen 5~50g, add purified water to 1000g, pack , freeze-dried, filled with nitrogen, plugged, crimped cap packaging. Leucine borate 0g~10g, valine borate 0g~10g, alanine borate 0g~10g, N-acetylcysteine ​​0g~10g, propylene glycol 0g~5g, Zorn 0g~5g, pH5.0~ 7.5 Add PBS to 1000g, subpackage, crimp the cap, and sterilize with steam at 105°C for 20 minutes.

[0024] The cell growth factor compound preparation described in Example 1 is suitable for pressure introduction, scrubbing and exfoliation introduction, microwave radio frequency introduction, ultrasound introduction, electrophoresis introduction and combination thereof.

Embodiment 2

[0026] Measure rhPDGF 0.01g-0.1g, TGF 0.001g-0.1g, HA 5g-20g, mannitol 10-100g, add purified water to 1000g, subpackage, freeze-dry, fill with nitrogen, press the plug, crimp the cap to seal. Add 10-100g of dextran, 5-50g of water-soluble collagen, and PBS with pH 5.0-7.5 to 1000g, subpackage, crimp and seal, and sterilize with steam at 105°C for 20 minutes.

[0027] The cell growth factor compound preparation described in Example 2 is suitable for microneedle introduction, scrubbing and exfoliation introduction, injection introduction, intradermal injection introduction, laser introduction and combination thereof.

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Abstract

The invention discloses a cosmetic method for repairing skin wrinkle and pitting defect, which includes that dermis trace intervention surgery is adopted to deliver composite preparation which contains biological active components and consists of recombinant human Platelet-Derived Growth Factor (rhPDGF) with dermis repairing function, Transforming Growth Factor (TGF) and Hyaluronic Acid (HA) into dermis for stimulating the growth and mitosis of fibroblast, the synthesis and secretion of collagen and HA, the generation and repairing of original fiber and flexibility fiber so that the skin defects of skin pitting, deep wrinkle and dermis fiber tissue fracture are repaired for a long term, and the skin beautifying and anti-aging effect are realized.

Description

technical field [0001] The invention discloses a new beauty application of recombinant human transforming growth factor and recombinant human platelet-derived growth factor. The technical field involved in the patent is the application of interventional medicine and biopharmaceutical technology in the fields of skin beauty and anti-aging. Background technique [0002] The skin is the largest organ of the human body, with a total weight of 5% to 15% of the body weight and a total area of ​​1.5 to 2 square meters. The skin has the function of maintaining the stability of the internal environment of the human body, preventing the loss of water, electrolytes and other nutrients in the body, and acting as a barrier to prevent the invasion of harmful substances from the outside. It plays an important protective function physiologically. Important signs and signs have important cosmetic functions. Skin damage happens from time to time, and skin aging is inevitable. [0003] Skin ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P17/00A61K31/728
Inventor 孙杰
Owner 孙杰
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