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Medicine combination containing isosorbide mononitrate for treating high blood pressure

A technology of isosorbide dinitrate and high blood pressure, which is applied in the field of medicine, can solve problems such as increased pulse pressure, and achieve the effects of reducing systolic blood pressure and pulse pressure difference, reducing arterial pressure, and lowering blood pressure

Active Publication Date: 2010-07-28
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Nowadays, for the treatment of hypertension, a single drug often cannot achieve the desired effect. In clinical practice, two or more antihypertensive drugs are often used in combination to achieve better antihypertensive effect, but it still cannot overcome the arterial A phenomenon in which the pulse pressure increases while the blood pressure decreases

Method used

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  • Medicine combination containing isosorbide mononitrate for treating high blood pressure
  • Medicine combination containing isosorbide mononitrate for treating high blood pressure
  • Medicine combination containing isosorbide mononitrate for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Isosorbide Mononitrate Nitrendipine Extended Release Tablets

[0020] Prescription A

[0021] Isosorbide Mononitrate 15g

[0022] Starch 50g

[0023] L--HPC 20g

[0024] 10% starch slurry appropriate amount

[0025] Magnesium Stearate 1g

[0026] Prescription B

[0027] Nitrendipine 15g

[0028] HPMC--4M 20g

[0029] HPMC--15M 30g

[0030] Microcrystalline Cellulose 20g

[0031]PVP 8g

[0032] Micronized silica gel 35g

[0033] 8% PVPk30 absolute ethanol solution appropriate amount

[0034] Magnesium Stearate 2g

[0035] Preparation Process:

[0036] Pass the isosorbide mononitrate, starch, and L-HPC in prescription A through a 100-mesh sieve, mix well, add 10% starch slurry to granulate, dry below 50°C, granulate with a 18-mesh sieve, and add stearic acid Magnesium mix well; pass nitrendipine, HPMC--4M, HPMC--15M, microcrystalline cellulose, PVP, and micropowder silica gel in prescription B respectively through a 100-mesh sieve, mix well, add an appropria...

Embodiment 2

[0038] Isosorbide Mononitrate Captopril Tablets

[0039] Isosorbide Mononitrate 10g

[0040] Captopril 50g

[0041] Starch 60g

[0042] Microcrystalline Cellulose 100g

[0043] L-HPC 30g

[0044] 10% starch slurry appropriate amount

[0045] Magnesium Stearate 2g

[0046] Preparation Process:

[0047] Pass the isosorbide mononitrate, captopril, starch, microcrystalline cellulose and L-HPC in the prescription through a 100-mesh sieve respectively, mix well, add 10% starch slurry to granulate in an appropriate amount, dry below 50°C, and dry for 18 Mesh sieve for granulation, add prescription amount of magnesium stearate, mix evenly, and compress into tablets.

Embodiment 3

[0049] Isosorbide Mononitrate Nifedipine Extended Release Tablets

[0050] Prescription A

[0051] Isosorbide Mononitrate 20g

[0052] Starch 100g

[0053] Sodium carboxymethyl starch 10g

[0054] 10% starch slurry appropriate amount

[0055] Magnesium Stearate 1g

[0056] Prescription B

[0057] Nifedipine 15g

[0058] Cetyl Alcohol 10g

[0059] Glyceryl monostearate 20g

[0060] Microcrystalline Cellulose 40g

[0061] 8% PVPk30 absolute ethanol solution appropriate amount

[0062] Magnesium Stearate 2g

[0063] Preparation Process:

[0064] Pass the isosorbide mononitrate, starch, and sodium carboxymethyl starch in prescription A through a 100-mesh sieve, mix well, add 10% starch slurry to granulate, dry below 50°C, granulate with a 18-mesh sieve, add hard Magnesium stearate and mix well; pass the nifedipine, cetyl alcohol, glyceryl monostearate and microcrystalline cellulose in prescription B respectively through a 100-mesh sieve, mix well, add 8% PVPk30 absolut...

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Abstract

The invention provides a medicine combination containing isosorbide mononitrate and an angiotensin receptor antagonist. Experiments show that the isosorbide mononitrate and the angiotensin receptor antagonist exert good cooperative functions in lowering blood pressure of patients and preventing complications of the patients suffering from high blood pressure. The medicine combination not only can effectively protect organ injury caused by high blood pressure, but also can effectively increase the long-term survival rate of the patients suffering from high blood pressure.

Description

technical field [0001] This application is a divisional application of the patent application with the application number 200510125589.9 and the invention name "Pharmaceutical Composition Containing Isosorbide Mononitrate for Treating Hypertension" filed on November 23, 2005. [0002] The invention belongs to the medical technology and relates to a new pharmaceutical composition for the treatment of elderly hypertension. Background technique [0003] New developments in the theory of drug therapy for hypertension [0004] In the treatment of hypertensive patients, paying attention to whether the long-term survival rate of patients has been significantly improved is a great progress in the theory of hypertension treatment in recent years. Previously, it was thought that diastolic blood pressure (DBP) was a better indicator to determine the severity of hypertension, and the goal of drug treatment was to reduce DBP to less than 90, 85 or 80mmHg. Systolic blood pressure (SBP) ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/34A61K31/4178A61K31/41A61P9/12
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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