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Method for preparing oryzanol microemulsion

A technology of microemulsion and oryzanol, applied in the field of preparation of oryzanol microemulsion, can solve the problems of inability to store for a long time, turbid thermodynamics, easy blocking of capillaries and the like

Inactive Publication Date: 2010-08-11
ZHANJIANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size of the emulsion droplets is between 100-10000nm. Although the amount of drug dissolved is relatively large, the emulsion is a polydisperse, turbid, thermodynamically unstable multi-phase system, which cannot be stored for a long time, and due to the large particle size, it is easy to block when used as an injection capillaries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: 28 ℃, light yellow clear microemulsion, by weight percentage, oryzanol content is 0.68%-1.13%, isopropyl myristate 2.98%-4.94%, glycerol 7.50%-12.45%, emulsifier 9.38 %-15.56%, the amount of water is 65.93%-79.45%. Oryzanol is dissolved in isopropyl myristate, using Tween 80 as emulsifier, glycerin as auxiliary agent, adding water and stirring.

Embodiment 2

[0020] Embodiment 2: 25 ℃, light yellow clear microemulsion, by weight percentage, oryzanol content is 0.51%-2.78%, coconut oil 1.77%-9.72%, glycerol 3.03%-16.67%, emulsifier 3.75%-20.83% , the water content is 50.00%-90.91%. Oryzanol is dissolved in coconut oil, using Tween 85 as emulsifier, glycerin as auxiliary agent, adding water and stirring.

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PUM

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Abstract

The invention relates to a method for preparing oryzanol microemulsion. The transparent or most transparent, clear and stable microemulsion is prepared by dissolving oryzanol into plant oil, adopting a nonionic surface active agent as an emulsifying agent, adopting fatty alcohol as an auxiliary agent and adding water or a sodium chloride aqueous solution and stirring. The oryzanol content in the microemulsion can be adjusted in a certain range as required, the maximal content of the oryzanol is 3 percent by weight, and the water content is in a range of 50-91 percent. The particle diameter of a microemulsion drop is in a range of 8-100nm, and the microemulsion is not turbid and is not delaminated in a temperature range of 20-90 DEG C. The oryzanol microemulsion prepared by the invention has transparent or most transparent, clear and stable property, the oryzanol content in the microemulsion can be adjusted in the certain range as required, and the maximal content of the oryzanol is 3 percent. The water content is in the range of 50-91 percent. The particle diameter of the microemulsion drop is in the range of 8-100nm. The microemulsion is not turbid and is not delaminated in the temperature range of 20-90 DEG C.

Description

technical field [0001] The invention belongs to a preparation method of oryzanol microemulsion. Background technique [0002] 1 Overview [0003] Oryzanol can regulate diencephalon function, improve autonomic dysfunction, endocrine balance disorder, and mental nervous disorder. It is mainly used for periodic psychosis, climacteric syndrome, premenstrual tension disorder, sequelae of concussion, vascular headache, autonomic dysfunction and neurosis. In recent years, clinical practice has concluded that it has a significant effect on the treatment of peptic ulcer, chronic gastritis, irritable bowel syndrome, gastroptosis, bacillary dysentery, hyperlipidemia, and pica in children. Due to the water insolubility of oryzanol, the current clinical medication is mainly tablets, which have low bioavailability, general curative effect, and a long course of treatment (the usual oral dose is 10-20 mg each time, 3 times a day, for 3 months. A treatment). In order to maximize the bioa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/575A61K47/44A61K47/34A61P25/00A61P15/12A61P1/04A61P1/00A61K47/10A61K47/14A61K47/26
Inventor 莫春生
Owner ZHANJIANG NORMAL UNIV
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