Bacillus anthracis capable of showing PA20 protein on surface of spore and application thereof

A Bacillus anthracis, surface display technology, applied in the direction of bacteria, antibacterial drugs, bacterial antigen components, etc., can solve the problems of side effects, residual toxicity, etc.
CN101798565AActive Publication Date: 2010-08-11INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Publication Date
2010-08-11

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Abstract

The invention discloses a bacillus anthracis capable of showing a PA20 protein on the surface of a spore and an application thereof. The bacillus anthracis is obtained by inserting a pagA20 gene into the tail end of a bacillus anthracis spore protein bcIA gene; and particularly the bacillus anthracis can be a bacillus anthracis CGMCC No.3403. The bacillus anthracis can serve as a host and is used for preparing, an immunomodulator which is preferably an inactivated vaccine, an attenuated live vaccine, a subunit vaccine or a gene engineering vaccine.
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Description

technical field

[0001] The present invention relates to a strain capable of displaying PA on the surface of spores 20 Proteins of Bacillus anthracis and their applications. Background technique

[0002] The anthrax spore attack after 9 / 11 caused people to panic about biological weapons. The spores formed by Bacillus anthracis have a long survival time, are easy to spread, and cause anthrax bacillosis with fast onset time and high mortality. It is listed as a Class B infectious disease in my country and is one of the weapons of choice for terrorists.

[0003] The virulent strain of B. anthracis contains two large plasmids, which are pXO1 plasmid (184.5kbp) encoding toxin base and pXO2 plasmid (95.3kbp) for synthesizing capsule-related genes. Strongly virulent strains require the existence of two kinds of plasmids. If pXO1 is lacking, no toxin will be produced, which means attenuated bacteria; if pXO2 is lacking, capsules will not be formed, which is a hundred times less vir...

Claims

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