Pretreatment method of propolis effective component raw material by supercritical extraction

An active ingredient and pretreatment technology, which is applied in the direction of medical preparations containing active ingredients, unknown raw materials, medical raw materials derived from arthropods, etc., can solve unfavorable extraction and extraction kettle cleaning, sticking to the extraction kettle wall, and affecting extraction Efficiency and other issues, to achieve the effect of cheap solution, easy to clean, and improve extraction efficiency

Inactive Publication Date: 2010-08-18
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pulverized crude propolis is soft and viscous at normal temperature. If it is directly put into the extraction kettle for supercritical extraction, it is easy to agglomerate and stick to the wall of the extraction kettle, which is not conducive to further extraction and cleaning of the extraction kettle. Affect extraction efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Freeze the crude propolis at -18°C for 6 to 24 hours, crush it, add 10 times the pretreatment solution, stir for five minutes, let it stand for one hour, separate the impurities in the upper layer, filter the lower layer sample, and dry the filter residue before ultra-thinning. Critical CO 2 extraction. The pretreatment solution is 8% ethanol solution.

Embodiment 2

[0011] After freezing the crude propolis, crush it, add 14 times the pretreatment liquid, stir for five minutes, let it stand for one hour, separate the impurities in the upper layer, filter the lower layer sample, and dry the filter residue before supercritical CO 2 extraction.

[0012] The pretreatment liquid is 10% ethylene glycol solution.

Embodiment 3

[0014] After freezing the crude propolis, crush it, add 12 times the pretreatment solution, stir for five minutes, let it stand for one hour, separate the impurities in the upper layer, filter the lower layer sample, and dry the filter residue before supercritical CO 2 extraction.

[0015] The pretreatment liquid is 15% ethylene glycol solution.

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PUM

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Abstract

The invention belongs to the chemical technology field of natural product, particularly relating to a pretreatment method of a propolis effective component raw material by supercritical extraction. The invention is realized by the following mode: freezing raw material rough propolis at the temperature of -18 DEG C for 6-24 hours; after being smashed, processing with 5-20 times of pretreatment solution; after standing, separating impurities on the upper layer, filtering other parts, and carrying out supercritical CO2 extraction after filter residues are dried. The pretreatment solution is one of the solutions or the mixture of a plurality of solutions of ethanol, glycol and water. The propolis raw material processed by the invention dose not block, does not adhere to extraction kettle wall and is easy to clean in the supercritical CO2 extraction process. The invention has simple operation and cheap solution, does not generate any side effect on products, reduces equipment cleaning time, energy consumption cost and the like and improves extraction efficiency.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and in particular relates to a raw material pretreatment method for supercritical extraction of active ingredients of propolis. Background technique [0002] Propolis is an aromatic jelly that is processed by honey bees from the resinous secretions of new branches, leaves, buds or bark of plants and mixed with the secretions of their mandibular glands and other glands and beeswax. A large number of active ingredients similar to collagen plants. Since propolis has the functions of anti-virus, lowering blood fat, anti-oxidation, and improving immunity, more and more researches have been done on the extraction methods of its active ingredients in recent years. Supercritical CO 2 The method of extracting the effective components of propolis has attracted people's attention. However, the pulverized crude propolis is soft and viscous at normal temperature. If it is directly put int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P31/12A61P3/06A61P39/06A61P37/04A61K35/644
Inventor 董玮玮鲁润华
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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