Technological measure for enhancing content uniformity of clenbuterol hydrochloride and application thereof

Abstract

The invention relates to a technological measure for enhancing the content uniformity of clenbuterol hydrochloride and application thereof. A technological method comprises the following steps: dissolving the clenbuterol hydrochloride and a pharmacologically-acceptable carrier in a solvent to prepare solution or suspension; and drying the solution or the suspension to form dry particles or powder.

Description

technical field The invention relates to a medicine preparation technology, in particular to the dispersion technology of clenbuterol hydrochloride, a respiratory system medicine. The invention uniformly disperses the clenbuterol hydrochloride, thereby improving the content uniformity. Background technique Clenbuterol hydrochloride (clenbuterol, CLB), a respiratory system drug, the chemical name is 2-[(tert-butylamino)methyl]-4-amino-3,5-dichlorobenzyl alcohol hydrochloride, the English name is : Clenbuterol; Spiropent; Planipart; NAB365; 4-Amino-3,5-dichloro-alpha-((1,1-dimethylethyl)ami-no)methyl)benzenemethanol. Molecular formula is C 12 h 19 Cl 3 N 2 O, molecular weight 313.5, melting point 174-175.5°C, colorless microcrystalline powder, odorless, slightly bitter taste, easily soluble in water, methanol, ethanol, slightly soluble in chloroform, insoluble in benzene. The structural formula is as follows: The drug was synthesized for the first time in 1972 and recor...

AI Technical Summary

Problems solved by technology

In order to overcome the problem that the content uniformity of clenbuterol hydrochloride cannot meet the requirements due to the low content of clenbuterol hydrochloride in the medicine, the present invention provides a technical means that can improve the content uniformity of clenbuterol hydrochloride, so that the The content uniformity of clenbuterol hydrochloride can meet the requirements

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