Unlock instant, AI-driven research and patent intelligence for your innovation.

Hepatitis C resistant plant extracts composition

A technology of plant extracts and compositions, which is applied in the direction of drug combinations, plant raw materials, plant/algae/fungus/moss components, etc., and can solve problems such as unknown proanthocyanidin hepatitis C

Active Publication Date: 2012-09-19
IND TECH RES INST
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, it can be seen from the above that proanthocyanidins are a pair of natural compounds that are very beneficial to health. However, it is still unclear whether proanthocyanidins can effectively inhibit hepatitis C

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hepatitis C resistant plant extracts composition
  • Hepatitis C resistant plant extracts composition
  • Hepatitis C resistant plant extracts composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 1 kg of Polygonum chinense raw medicinal material at room temperature, shake and extract with 95wt% ethanol at 120rpm for 3 days, filter and separate the extract, concentrate under reduced pressure, and concentrate to the minimum on the premise that there will be no attachment on the bottle wall Volume, freeze-dried, that is, the wine crude extract layer. Take 90g, add water: ethanol (volume ratio) = 95:5 to dissolve, and then carry out liquid-phase-liquid-phase extraction with n-hexane, diethyl ether, and ethyl acetate in sequence to obtain n-hexane layer, diethyl ether, and ethyl acetate products. The extraction procedure is as follows:

[0029] Mix the solution of Motherwort root with n-hexane and place it in a separatory funnel, mix and shake well, let stand to separate layers, and take the upper layer. Repeat the action three times to obtain the n-hexane layer. Add diethyl ether to the lower layer (water layer) and put it in a separatory funnel, mix and shak...

Embodiment 2

[0040] 1. Take 5g of Polygonum chinense raw medicinal material at room temperature, add 50ml of pure water to soak, shake and extract at 120rpm for 24 hours, concentrate and dry under reduced pressure. Take 0.0676g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 58.7±5.9% at a concentration of 50 μg / ml.

[0041] 2. Same as step 1, change the solvent to 50ml of acetone. Take 0.0043g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 88.7±1.3% at a concentration of 50 μg / ml.

[0042] 3. Same as step 1, change the solvent to acetone: water = 1: 1, a total of 50ml. Take 0.0488g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 87.3±1.9% at a concentration of 50 μg / ml.

[0043] 4. Same as step 1, change the solvent to acetone: water = 1: 2, a total of 50ml. Take 0.0082g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 79.9±2.2% at a concentration ...

Embodiment 3

[0054] 1. Take 5g of raw medicinal material extracted from grape seeds (commercially available grapes) at room temperature, and add 50ml of pure water. Take 0.236g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 81.6±3.3% at a concentration of 50 μg / ml.

[0055] 2. Same as step 1, change the solvent to 50ml of acetone. Take 0.687g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate (%) is 5±12.2.

[0056] 3. Same as step 1, change the solvent to acetone: water = 1: 1, a total of 50ml. Take 0.1164g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 82.1±4.7% at a concentration of 50 μg / ml.

[0057] 4. Same as step 1, change the solvent to acetone: water = 1: 2, a total of 50ml. Take 0.034g, and test it for inhibiting hepatitis C virus activity, and the inhibition rate is 87.3±2.9% at a concentration of 50 μg / ml.

[0058] 5. Same as step 1, change the solvent to acetone: water = 2:...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
control rateaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
degree of polymerizationaaaaaaaaaa
Login to View More

Abstract

The invention provides a hepatitis C resistant plant extracts composition, comprising an effective amount of oligomeric proanthocyanidins and a pharmaceutically acceptable carrier or salt; wherein the extraction sources of the oligomeric proanthocyanidins include grade pip, Chinese knotweed herb, ampelopsis brevipedunculata var. hancei and ampelopsis cantoniensis (Hook. & Arn.) planch which have better hepatitis C resistant effect, and the molecular formula of monomer of the oligomeric proanthocyanidins is shown as follows.

Description

technical field [0001] The present invention relates to an anti-hepatitis C composition, and particularly relates to a plant extract composition containing oligomeric proanthocyanidins, which can inhibit the activity of hepatitis C virus. Background technique [0002] 2-3% (about 300 million people) of the population is infected with hepatitis C in the whole world, and it spreads at a rate of 3-4 million new patients every year. At present, the only proven and approved anti-HCV drug is alpha (alpha) interferon (α-Interferon), while ribavirin (ribavirin) is a proven and approved anti-hepatitis C drug with enhanced alpha interferon. Anti-hepatitis C virus efficacy. However, both of them will have serious side effects, and most of them have the phenomenon of drug resistance. [0003] The biochemical and pharmacological activities of proanthocyanidins are known so far, including antioxidant activity, enzyme inhibitory activity, antimutagenic activity, reducing capillary permea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353C07D311/62A61K36/87A61K36/704A61P31/12A61P1/16
Inventor 李连滋张秀凤林铮殷韶禅邱淑娇
Owner IND TECH RES INST
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com