Conductive polyaniline with bioactivity, preparation thereof and use thereof

Abstract

The invention discloses an in-situ electrochemical combinatorial synthesis method, which is adopted to copolymerize a phenylamine derivative monomer with bioactive units and phenylamine in solution in a manner of active radical polymerization on an electrode to form conductive polyaniline with bioactivity in situ on the electrode directly by one step, a microelectrode array technique adopting independent addressing and technique for preparing functional microelectrode arrays by using the conductive polyaniline with bioactivity. The method and the techniques solve the long-existing problem of the academic circles that the bioactive unit can be actively and permanently combined with a metal while bioactive molecules can be grafted with a conductive polymer in place by one step, lay a function for unmarked analysis methods, make biosensors develop toward microminiaturization and integration, make the automatic production of protein chips on an operable level possible, promote the development of things Internet industrial chain and have a profound social significance and high market value.

Description

technical field The present invention relates to a kind of conductive polyaniline with biological activity and its preparation method and application, specifically, it relates to a method of in-situ electrochemical combination synthesis (combinatorial synthesis) to make the aniline derivative monomer with biological activity unit Copolymerize with aniline in the solution on the electrode by living radical polymerization, generate bioactive conductive polyaniline directly on the electrode in situ in one step, and use independently addressable microelectrode array technology to apply the biologically active polyaniline Fabrication of functionalized microelectrode arrays from conductive polyaniline. Background technique Due to their special structure and excellent physical and chemical properties, conductive polymers have broad application prospects in the fields of optics, electromagnetism and chemistry. In recent years, the application of conductive polymers in the field of ...

AI Technical Summary

Problems solved by technology

Due to the existence of chain transfer and chain termination reactions, traditional free radical polymerization cannot control the molecular weight and macromolecular structure well

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