Method for building Alzheimer's disease (AD) morbidity-associated gene network path analyzing model
A technology of gene network and establishment method, which is applied in the field of building AD pathogenesis-related gene network pathway to achieve the effect of easy operation and simple method
Inactive Publication Date: 2010-08-25
NANTONG UNIVERSITY
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As for the application of gene expression quantitative trait locus mapping technology to the research of AD and other diseases, there are no related reports at home and abroad.
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The invention discloses a method for building an Alzheimer's disease (AD) morbidity-associated gene network path analyzing model, which comprises the following steps of: collecting the known AD morbidity-associated genes by using a bioinformatics method; performing analysis of genetic genomics by means of gene expression data and gene-type data of B*D gene recombinant inbred mice to screen out upstream regulating loci with statistical significance; performing verification of cis-eQTL authenticity and candidate genes screening verification; and determining the synergic or regulatory relation of the AD morbidity-associated genes to build the gene expression regulating network path of the AD morbidity-associated genes. The method is simple and convenient and easy to operate; and the AD morbidity-associated gene network path analyzing model can be effectively built by the method.
Description
Establishment method of gene network pathway analysis model related to AD pathogenesis Technical field: The invention relates to a method for constructing a gene network pathway related to AD pathogenesis. Background technique: Alzheimer's disease (Alzheimer's disease, AD) is one of the most common degenerative diseases of the central nervous system. It affects the health and life of the elderly and has become one of the major diseases that seriously endanger human health in modern society. The main pathological features of AD are brain atrophy, senile plaques (senile plaque, SP), neurofibrillary tangles (neurofilament tangles, NFTs) and cerebral vascular deposits formed in the brain tissue. The results of neuropathological studies on the brain tissue of AD patients show that there are extensive losses of components of the cholinergic or noradrenergic system in the cerebral cortex, hippocampus, basal forebrain, and locus coeruleus, among which the hippocampus is a major ...
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IPC IPC(8): C12Q1/68
Inventor 陆璐王晓冬陈颖徐邦生陈雪王勇军谢晓玲
Owner NANTONG UNIVERSITY