Salen Zn (II) coordination compound and preparation method and application thereof

Abstract

The invention discloses a Salen Zn (II) coordination compound and a preparation method and application thereof. The Salen Zn (II) coordination compound has a cation structure as shown in a general formula (I). The invention optimizes a preparation process of a Salen metal coordination compound, shortens the reaction time and enhances the productivity; and the obtained Salen Zn (II) coordination compound has very good water solubility. The Salen Zn (II) coordination compound forms a coordination bond by utilizing the axial coordination capability of the Salen metal coordination compound and an electron donor contained in a single chain part basic group of an RNA (Ribonucleic Acid) structure and is an RNA composite reagent which has more affinity compared with electrostatic interaction and weak interaction, i.e. hydrophobic interaction, hydrogen bond, Pi-Pistacking, and the like, thereby more effectively blocking the reverse transcription of a reverse transcriptase on virus RNA and providing a certain theoretical foundation for the development of drugs for treating major diseases (such as Aids, cancers, leukemia, and the like) caused by reverse transcriptase viruses.

Description

technical field The invention relates to an RNA binding reagent or an RNA reverse transcriptase inhibitor, in particular to a Salen Zn(II) complex and a preparation method and application thereof. Background technique A "retrovirus" is a virus that carries the enzyme reverse transcriptase. Unlike most living things, this virus does not have DNA, but RNA as its genetic material. When these viruses invade host cells, they can also transcribe genetic information from single-stranded viral RNA to DNA. This process is opposite to the direction of general transcription, so it is called "reverse transcription", and the enzyme that catalyzes this process is called "reverse transcriptase". Under the action of reverse transcriptase, the virus first converts RNA into cDNA, and then proliferates under the actions of DNA replication, transcription, and translation. Retroviruses are RNA viruses, which are directly responsible for the generation and spread of diseases such as AIDS and l...

AI Technical Summary

Problems solved by technology

They can cause changes in the conformation of the enzyme by interacting with reverse transcriptase, thereby reducing the recognition of the substrate and the enzyme

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