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Heparin rectum iontophoretic drug delivery system

An iontophoresis and drug delivery system technology, which is applied in the field of using iontophoresis technology combined with drug delivery devices, can solve the problems of patients with long treatment cycles, inconvenience, etc., to avoid the first pass effect, increase the absorption in the body, and reduce the damage to the body. Effect

Active Publication Date: 2010-09-22
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such frequent injections and long treatment cycles have caused great inconvenience to patients, especially middle-aged and elderly patients

Method used

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  • Heparin rectum iontophoretic drug delivery system
  • Heparin rectum iontophoretic drug delivery system
  • Heparin rectum iontophoretic drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] prescription:

[0064] Heparin 200,000IU

[0065] Carrier gelatin 20g

[0066] Sodium deoxycholate 3g

[0067] water 100ml

[0068] The average molecular weight of heparin is 14,000Da;

[0069] Preparation:

[0070] Mix heparin, mucosal absorption accelerator, dispersion medium and carrier, stir, vacuum degassing to obtain a drug mixture, then fill in capsules, punch holes in the capsules, insert the second electrode, and connect the second electrode with the battery The negative pole of the battery is connected, and the battery is fixed on one end of the capsule, and then one end of the first electrode is connected to the positive pole of the battery through a resistance, and the structure is as follows figure 1 .

Embodiment 2

[0072] Low Molecular Weight Heparin 200,000IU

[0073] Polyoxyethylene 5g

[0074] Macrogol Caprylic / Capric Glycerides 5g

[0075] water 100ml

[0076] The average molecular weight of the low molecular weight heparin is 5000Da; the polyoxyethylene model is WSR303, and the preparation method is the same as in Example 1.

Embodiment 3

[0078] Heparin 500,000IU

[0079] Carrier Hypromellose 5g

[0080] N-Methylpyrrolidone 6g

[0081] 100ml of water.

[0082] Heparin has an average molecular weight of 15,000 Da. The model of hydroxypropylmethylcellulose used in the examples is K100M.

[0083] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a heparin rectum iontophoretic drug delivery system comprising a capsule (1), a drug (2), a power supply (3), a first electrode (4) , a second electrode (5) and a control device (6), wherein the surface of the capsule (1) is provided with a small drug release hole (101), and the drug (2) is filled in the capsule (1); one end of the control device (6) is connected with one end of the power supply (3) and the other end is connected with the first electrode (4), and the other end of the power supply (3) is connected with the drug (2) by the second electrode (5) or withoutthe second electrode (5). The heparin rectum iontophoretic drug delivery system has fast acting, can avoid first-pass effect and facilitates a doctor of randomly adjusting or suspending dose progressaccording to the treatment condition of a patient. Pharmacokinetics data with animal drug delivery show that by adopting the system to deliver the drug through rectum of animals, internal absorption of the drug is obviously increased compared with oral or nonionic electroosmosis rectum drug delivery, thereby the system can substitute drug delivery by subcutaneous injection.

Description

technical field [0001] The invention relates to a rectal iontophoresis drug delivery system for heparin, in particular, the iontophoresis technology combined with a drug delivery device is used to help the drug to be absorbed through the rectal mucosa. Background technique [0002] Heparin is a type of glycosaminoglycan with a molecular weight of about 4,000-20,000 Da. Low-molecular-weight heparin is obtained by degradation or depolymerization of heparin, with a molecular weight of about 3,000-8,000 Da. 2-O-sulfate-α-L iduronic acid and 6-O-sulfate-N-sulfate-α-D glucosamine are the main monosaccharides of the two, and the repeating unit of the trisulfate disaccharide composed of them is The main part of heparin and low molecular weight heparin. As an effective anticoagulant drug, heparin and low molecular weight heparin are commonly used clinically to prevent and treat various thromboembolism and ischemic diseases such as deep venous thrombosis, pulmonary embolism, cerebral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61M31/00
Inventor 侯惠民李丁
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT