Tanshinone II A derivative and preparation method and application thereof

Abstract

The invention discloses a tanshinone II A derivative and a preparation method and application thereof. The structural formula of the tanshinone II A derivative is as shown in Formula (I). The preparation method adopts tanshinone II A and aldehydes for synthesis and has the advantages of safe and simple operation and high yield. The tanshinone II A derivative has a function of inhibiting the growth of tumor cells, can be applied in preparation of anti-tumor drugs and has potential value for industrial development and great significance for research and development of anticancer drugs.

Description

technical field The invention relates to the field of tanshinone IIA compounds, in particular to a tanshinone IIA derivative and a preparation method and application thereof. Background technique Malignant tumor is a disease that seriously endangers people's life and health, and the death toll is second only to cardiovascular disease. Although the history of chemotherapy for tumors is short, it has developed rapidly and has become the main treatment method besides surgery and radiotherapy. However, most chemotherapy drugs used today have defects such as high systemic toxicity, easy drug resistance and drug resistance. Now, the focus of tumor drug research has shifted to the synthesis of some compounds with good anti-tumor activity and low toxicity and low mutagenicity to normal cells. In the process of drug design, it has always been the focus and difficulty of medicinal chemistry research to improve biological activity, improve therapeutic targeting, reduce systemic toxic...

AI Technical Summary

Problems solved by technology

However, most of the chemotherapeutic drugs used today have defects such as high systemic toxicity, easy drug resistance and drug resistance

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